Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00465
Abstract: The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be associated with… read more here.
Keywords: gmp; gmp quadruplex; quadruplex inducers; biofilm inhibitors ... See more keywords
Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02517
Abstract: The ubiquitous opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes biofilm-associated drug-resistant infections that often lead to treatment failure. Targeting the bacterium's quorum sensing (QS) and iron homeostasis presents a promising strategy to combat biofilm formation.… read more here.
Keywords: hydroxamic acid; pseudomonas aeruginosa; dual acting; biofilm ... See more keywords
Thiosemicarbazones and analogues as potential biofilm inhibitors of Candida albicans
Sign Up to like & getrecommendations! Published in 2025 at "Biofouling"
DOI: 10.1080/08927014.2025.2457151
Abstract: Abstract Biofilms are a virulence factor for Candida albicans, a common pathogen in human fungal infections, making them resistant to many commercial antifungals. Therefore, the discovery of compounds that inhibit and eradicate biofilms is a… read more here.
Keywords: analogues potential; inhibitors candida; candida albicans; biofilm inhibitors ... See more keywords
Synthesis, In Silico, and In Vitro Evaluation of Long Chain Alkyl Amides from 2-Amino-4-Quinolone Derivatives as Biofilm Inhibitors
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DOI: 10.3390/molecules24020327
Abstract: Infection from multidrug resistant bacteria has become a growing health concern worldwide, increasing the need for developing new antibacterial agents. Among the strategies that have been studied, biofilm inhibitors have acquired relevance as a potential… read more here.
Keywords: chain; inhibition; amino quinolone; long chain ... See more keywords
Biofilm-i: A Platform for Predicting Biofilm Inhibitors Using Quantitative Structure—Relationship (QSAR) Based Regression Models to Curb Antibiotic Resistance
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DOI: 10.3390/molecules27154861
Abstract: Antibiotic drug resistance has emerged as a major public health threat globally. One of the leading causes of drug resistance is the colonization of microorganisms in biofilm mode. Hence, there is an urgent need to… read more here.
Keywords: platform; quantitative structure; biofilm; resistance ... See more keywords
Elucidation of Antimicrobials and Biofilm Inhibitors Derived from a Polyacetylene Core
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DOI: 10.3390/molecules29245945
Abstract: The development of new antibiotics with unique mechanisms of action is paramount to combating the growing threat of antibiotic resistance. Recently, based on inspiration from natural products, an asymmetrical polyacetylene core structure was examined for… read more here.
Keywords: polyacetylene core; elucidation antimicrobials; antimicrobials biofilm; biofilm inhibitors ... See more keywords