Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13444
Abstract: Ribosomes, the cellular organelles translating the genetic code to proteins, are assemblies of RNA chains and many proteins (RPs) arranged in precise fine‐tuned interwoven structures. Mutated ribosomal genes cause ribosomopathies, including Diamond Blackfan anemia (DBA,… read more here.
Keywords: biogenesis; diamond blackfan; blackfan anemia;
Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506131
Abstract: Neuroblastoma (NB), a pediatric solid malignancy, is distinguished by hetergenous clinical characteristics, including tumor aggressiveness or spontaneous regression. Nevertheless, the regulatory mechanisms and therapeutic approaches underlying these processes are still mainly unknown. Herein, RAR‐related orphan… read more here.
Keywords: biogenesis; targeting rbm10; liquid condensates; lysosomal biogenesis ... See more keywords
Single‐molecule approaches reveal outer membrane protein biogenesis dynamics
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200149
Abstract: Outer membrane proteins (OMPs) maintain the viability of Gram‐negative bacteria by functioning as receptors, transporters, ion channels, lipases, and porins. Folding and assembly of OMPs involves synchronized action of chaperones and multi‐protein machineries which escort… read more here.
Keywords: single molecule; outer membrane; molecule approaches; biogenesis ... See more keywords
Type 2 diabetes mellitus stimulated pulmonary vascular inflammation and exosome biogenesis in rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3764
Abstract: It has been shown that type 2 Diabetes Mellitus (T2DM) changes the paracrine activity of several cell types. Whether the biogenesis of exosomes is changed during diabetic conditions is the subject of debate. Here, we… read more here.
Keywords: mellitus stimulated; biogenesis; type diabetes; stimulated pulmonary ... See more keywords
ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte‐like 3T3‐L1 cells
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12206
Abstract: ATAD3 is a vital ATPase of the inner mitochondrial membrane of pluri‐cellular eukaryotes, with largely unknown functions but early required for organism development as necessary for mitochondrial biogenesis. ATAD3 knock‐down in C. elegans inhibits at… read more here.
Keywords: biogenesis; adipogenesis; mitochondrial biogenesis; atad3 ... See more keywords
Recent insights into gap junction biogenesis in the cochlea
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.538
Abstract: In the cochlea, connexin 26 (Cx26) and connexin 30 (Cx30) co‐assemble into two types of homomeric and heteromeric gap junctions between adjacent non‐sensory epithelial cells. These channels provide a mechanical coupling between connected cells, and… read more here.
Keywords: recent insights; cx30; cochlea; biogenesis ... See more keywords
Mammalian iron sulfur cluster biogenesis and human diseases
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2597
Abstract: Fe-S cluster biogenesis is a multistep process that involves a complex sequence of catalyzed protein– protein interactions and coupled conformational changes between the components of several dedicated multimeric complexes. Intensive studies of the assembly process… read more here.
Keywords: mammalian iron; cluster biogenesis; biogenesis; sulfur cluster ... See more keywords
Atractylenolide I ameliorates cancer cachexia through inhibiting biogenesis of IL‐6 and tumour‐derived extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13079
Abstract: Atractylenolide I (AI) is a natural sesquiterpene lactone isolated from Atractylodes macrocephala Koidz, known as Baizhu in traditional Chinese medicine. AI has been found to ameliorate cancer cachexia in clinic cancer patients and in tumour‐bearing… read more here.
Keywords: extracellular vesicles; cancer cachexia; tumour derived; biogenesis ... See more keywords
Protective effects of PX478 on gut barrier in a mouse model of ethanol and burn injury
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0820-323rr
Abstract: Ethanol remains a confounder in postburn pathology, which is associated with an impaired intestinal barrier. Previously, we demonstrated that ethanol and burn injury reduce intestinal oxygen delivery (hypoxia) and alters microRNA (miR) expression in small… read more here.
Keywords: expression; burn injury; barrier; ethanol burn ... See more keywords
Mitochondrial biogenesis in neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24042
Abstract: Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. Adverse stimulations including neurodegenerative diseases may result in mitochondrial dynamic imbalance, free radical production, calcium accumulation, intrinsic cell death pathway activation… read more here.
Keywords: mitochondrial biogenesis; death; biogenesis neurodegeneration; pgc ... See more keywords
YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23105
Abstract: Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the… read more here.
Keywords: biogenesis; autophagy lysosomal; yy1 cooperates; biogenesis melanoma ... See more keywords