Applications of Bioisosteres in the Design of Biologically Active Compounds.
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DOI: 10.1021/acs.jafc.3c00765
Abstract: The design of bioisosteres represents a creative and productive approach to improve a molecule, including by enhancing potency, addressing pharmacokinetic challenges, reducing off-target liabilities, and productively modulating physicochemical properties. Bioisosterism is a principle exploited in… read more here.
Keywords: design bioisosteres; bioisosteres design; design; applications bioisosteres ... See more keywords