Evaluation of Biological Activity and Computer‐Aided Design of New Soft Glucocorticoids
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DOI: 10.1002/ardp.201600383
Abstract: Soft glucocorticoids are compounds that are biotransformed to inactive and non‐toxic metabolites and have fewer side effects than traditional glucocorticoids. A new class of 17β‐carboxamide steroids has been recently introduced by our group. In this… read more here.
Keywords: soft glucocorticoids; biological activity; activity computer; evaluation biological ... See more keywords
Co‐expression of alpha‐1 antitrypsin with cytoplasmic domain of v‐SNARE in Pichia pastoris: Preserving biological activity of alpha‐1 antitrypsin
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DOI: 10.1002/bab.1578
Abstract: Alpha‐1‐antitrypsin (A1AT) is a major serum protein in human with protease inhibitory activity. Because of its extensive application in medicine, recombinant DNA technology has been considered for its production. The current study examines coexpression of… read more here.
Keywords: biological activity; domain snare; cytoplasmic domain; alpha antitrypsin ... See more keywords
Conferring biological activity to native spider silk: A biofunctionalized protein‐based microfiber
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DOI: 10.1002/bit.26065
Abstract: Spider silk is an extraordinary material with physical properties comparable to the best scaffolding/structural materials, and as a fiber it can be manipulated with ease into a variety of configurations. Our work here demonstrates that… read more here.
Keywords: conferring biological; biological activity; silk; spider silk ... See more keywords
Synthesis and Biological Activity of Oxazolopyrimidines
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DOI: 10.1002/ejoc.201800133
Abstract: In this work, the synthesis of oxazolo[4,5-d]pyrimidines and oxazolo[5,4-d]pyrimidines is reviewed. The review is focused on the construction of the scaffold rather than on its further modification. Nevertheless, selected examples illustrate some of the most… read more here.
Keywords: biological activity; activity oxazolopyrimidines; chemistry; synthesis biological ... See more keywords
Polyphenolic compounds with biological activity in guabiroba fruits (Campomanesia xanthocarpa Berg.) by comprehensive two‐dimensional liquid chromatography
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DOI: 10.1002/elps.202000170
Abstract: This study aimed to evaluate the polyphenolic composition along with the biological activity of guabiroba (Campomanesia xanthocarpa Berg.) fruits using comprehensive two‐dimensional liquid chromatography (LC × LC). A simplex centroid design comprising three solvents (methanol,… read more here.
Keywords: campomanesia xanthocarpa; biological activity; activity guabiroba; guabiroba ... See more keywords
Chemistry and biological activity of resin glycosides from Convolvulaceae species
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DOI: 10.1002/med.21916
Abstract: Carbohydrate‐based drug discovery has gained more and more attention during the last few decades. Resin glycoside is a kind of novel and complex glycolipids mainly distributed in plants of the family Convolvulaceae. Over the last… read more here.
Keywords: chemistry; biological activity; chemistry biological; resin ... See more keywords
MolPredictX: Online Biological Activity Predictions by Machine Learning Models
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DOI: 10.1002/minf.202200133
Abstract: Here we report the development of MolPredictX, an innovate and freely accessible web interface for biological activity predictions of query molecules. MolPredictX utilizes in‐house QSAR models to provide 27 qualitative predictions (active or inactive), and… read more here.
Keywords: activity predictions; predictions machine; biological activity; molpredictx online ... See more keywords
Novel 1,3,4-oxadiazole sulfonate/carboxylate flavonoid derivatives: Synthesis and biological activity.
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DOI: 10.1002/ps.7197
Abstract: BACKGROUND With the long-term use of traditional bactericides and antiviral agents, drug resistance has become increasingly prominent, resulting in impaired crop growth and yields. Based on this, the introduction of small molecular active groups into… read more here.
Keywords: novel oxadiazole; sulfonate carboxylate; biological activity; carboxylate flavonoid ... See more keywords
Microstructure and biological activity of silicon‐doped composite coatings fabricated by micro‐arc oxidation on magnesium alloy
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DOI: 10.1002/sia.6913
Abstract: Among biomaterials, the mechanical properties of magnesium and its alloys are closest to those of human bone tissue, making these ideal materials for bone tissue repair and replacement. In order to further improve the biocompatibility… read more here.
Keywords: biological activity; micro arc; magnesium; silicon ... See more keywords
Biological activity of mannosylerythritol lipids on the mammalian cells.
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DOI: 10.1007/s00253-020-10857-9
Abstract: Mannosylerythritol lipids (MEL) are glycolipids mainly produced by pseudo-yeasts. These molecules present remarkable biological activities widely explored in many fields, including medicine, pharmaceuticals, and cosmetics. This review presents the main biological activity of MEL on… read more here.
Keywords: biological activity; mel; mammalian cells; mannosylerythritol lipids ... See more keywords
Studies on the constituents of Helleborus purpurascens: analysis and biological activity of the aqueous and organic extracts
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DOI: 10.1007/s00726-017-2502-6
Abstract: In Southeast Europe, the ethnomedicinal use of Helleborus species has a very long tradition. Cardiac steroids (Hellebrin), cysteine-rich proteins (Hellethionins) and several steroidal saponins have been identified in these plants. Aim of the present work… read more here.
Keywords: biological activity; constituents helleborus; analysis biological; purpurascens analysis ... See more keywords