Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201904337
Abstract: Engineered nanomaterials have been extensively employed as therapeutics for tumor management. Meanwhile, the complex tumor niche along with multiple barriers at the cellular level collectively hinders the action of nanomedicines. Here, the advanced strategies that… read more here.
Keywords: biological barriers; advances nanostrategies; nanostrategies capable; tumor management ... See more keywords
Piloting Your Nanovehicle to Overcome Biological Barriers.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6646-2_9
Abstract: Designing an effective nanoparticle for selective drug transport requires careful consideration of the complex biological barriers encountered in transit to the desired target. Here, we review several of these barriers, and provide possible methods for… read more here.
Keywords: biological barriers; overcome biological; nanovehicle overcome; nanoparticle ... See more keywords
Nanomedicines for developing cancer nanotherapeutics: from benchtop to bedside and beyond
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9352-3
Abstract: Cancer is a devastating disease and remains a significant cause of mortality and morbidity in both developed and developing countries. Although there are large number of drugs that can be used for the treatment of… read more here.
Keywords: cancer nanotherapeutics; biological barriers; nanomedicines developing; developing cancer ... See more keywords
Overcoming biological barriers to improve solid tumor immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-00923-8
Abstract: Cancer immunotherapy has been at the forefront of therapeutic interventions for many different tumor types over the last decade. While the discovery of immunotherapeutics continues to occur at an accelerated rate, their translation is often… read more here.
Keywords: tumor immunotherapy; tumor; biological barriers; solid tumor ... See more keywords
Light/gas cascade-propelled Janus micromotors that actively overcome sequential and multi-staged biological barriers for precise drug delivery
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2020.127897
Abstract: Abstract Passive diffusion-based drug delivery systems have indeed shown impressive performance to overcome a cascade of biological barriers, but the delivery efficiency is still modest. Although artificial micro/nanomotors are capable of autonomous movement, oriented navigation… read more here.
Keywords: biological barriers; drug delivery; delivery; drug ... See more keywords
Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.05.042
Abstract: The biological barriers in the body have been fabricated by nature to protect the body from foreign molecules. The successful delivery of drugs is limited and being challenged by these biological barriers including the gastrointestinal… read more here.
Keywords: polymeric nanoparticles; biodegradable polymeric; nanoparticles cross; biological barriers ... See more keywords
How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05317
Abstract: Biological barriers are essential physiological protective systems and obstacles to drug delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either causing adverse health impacts on humans or producing therapeutic opportunities. This Review… read more here.
Keywords: paracellular route; open paracellular; route; nanoparticles open ... See more keywords
Self-Assembled Peptide-Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.8b00081
Abstract: Developing a sophisticated nanomedicine platform to deliver therapeutics effectively and safely into tumor/cancer cells remains challenging in the field of nanomedicine. In particular, reliable peptide drug delivery systems capable of overcoming biological barriers are still… read more here.
Keywords: drug delivery; peptide lanthanide; biological barriers; peptide drug ... See more keywords
"Spear and shield in one" nanochaperone enables protein to navigate multiple biological barriers for enhanced tumor synergistic therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00409g
Abstract: Protein therapeutics have been viewed as powerful candidates for cancer treatment by virtue of highly specific bioactivity and minimized adverse effects. However, the intracellular delivery of protein drugs remains enormously challenging due to multiple successive… read more here.
Keywords: spear shield; therapy; biological barriers; tumor ... See more keywords
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002105
Abstract: The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for… read more here.
Keywords: overcoming biological; delivery; nucleic acid; biological barriers ... See more keywords
Determination of probiotic characteristics and resistance to biological barriers under in vitro gastrointestinal conditions in goat cheese produced using microencapsulated probiotic bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Food Science and Technology International"
DOI: 10.1590/fst.34620
Abstract: Goat milk, which is the most used one in cheese production among milk products, has the quality of being a very common raw material used in cheese production (Popović-Vranješ et al., 2017; Barłowska et al.,… read more here.
Keywords: probiotic characteristics; characteristics resistance; biological barriers; determination probiotic ... See more keywords