Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114476
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. Traditionally, this medicinal plant is mainly masticated or smoked… read more here.
Keywords: phytochemistry pharmacokinetics; clinical activities; tortuosum; pharmacokinetics biological ... See more keywords
Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2016.1273310
Abstract: ABSTRACT Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in… read more here.
Keywords: ido1; cutaneous cell; ctcl; biological clinical ... See more keywords
Dissociation and its biological and clinical associations in functional neurological disorder: systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "BJPsych Open"
DOI: 10.1192/bjo.2022.597
Abstract: Background Studies have reported elevated rates of dissociative symptoms and comorbid dissociative disorders in functional neurological disorder (FND); however, a comprehensive review is lacking. Aims To systematically review the severity of dissociative symptoms and prevalence… read more here.
Keywords: functional neurological; dissociation; neurological disorder; biological clinical ... See more keywords
Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00149
Abstract: Nuclear receptors (NRs) are ligand-inducible transcription factors that play critical roles in metazoan development, reproduction, and physiology and therefore are implicated in a broad range of pathologies. The transcriptional activity of NRs critically depends on… read more here.
Keywords: profiling 3696; coregulator interactions; coregulator; clinical discovery ... See more keywords
Subthreshold amyloid and its biological and clinical meaning
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007747
Abstract: The development of in vivo imaging of the pathologic hallmark of Alzheimer disease (AD), β-amyloid (Aβ), altered the framing of its pathophysiology and formulation of inclusion criteria for clinical trials. Recent evidence suggests that in… read more here.
Keywords: amyloid biological; subthreshold amyloid; pathology; clinical meaning ... See more keywords
Biological and Clinical Attributes of Sporothrix globosa, a Causative Agent of Sporotrichosis
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s362099
Abstract: Abstract Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa are the main etiological agents of this disease; and even… read more here.
Keywords: sporotrichosis; biological clinical; agent; sporothrix globosa ... See more keywords
Possible Biological and Clinical Applications of Phenothiazines.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.12045
Abstract: Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology. These compounds are able to effectively inhibit dopamine, histamine, serotonin, acetylcholine, and α-adrenergic receptors; thus, their effect and side-effect profiles are extremely diverse.… read more here.
Keywords: possible biological; applications phenothiazines; effect; clinical applications ... See more keywords
Controversies and expectations for the prevention of GVHD: A biological and clinical perspective
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1057694
Abstract: Severe acute and chronic graft versus host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. Historically, cord blood and matched sibling transplantation has been associated with the lowest… read more here.
Keywords: gvhd biological; controversies expectations; gvhd; biological clinical ... See more keywords
Biological and Clinical Changes in a Pediatric Series Treated with Off-Label JAK Inhibitors
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DOI: 10.3390/ijms21207767
Abstract: Off-label use of medications is still a common practice in pediatric rheumatology. JAK inhibitors are authorized in adults in the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. Although their use is not authorized… read more here.
Keywords: jak; interferon; clinical changes; series ... See more keywords
The Biological and Clinical Aspects of a Latent Tuberculosis Infection
Sign Up to like & getrecommendations! Published in 2022 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed7030048
Abstract: Tuberculosis (TB), caused by bacilli from the Mycobacterium tuberculosis complex, remains a serious global public health problem, representing one of the main causes of death from infectious diseases. About one quarter of the world’s population… read more here.
Keywords: tuberculosis; infection; biological clinical; aspects latent ... See more keywords