Benchmarking Molecular Dynamics Force Fields for All-Atom Simulations of Biological Condensates.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.3c00148
Abstract: Proteins containing intrinsically disordered regions are integral parts of the cellular signaling pathways and common components of biological condensates. Point mutations in the protein sequence, genetic at birth or acquired through aging, can alter the… read more here.
Keywords: molecular dynamics; force fields; force; biological condensates ... See more keywords
Liquid–Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14071830
Abstract: Simple Summary Emerging evidence shows that the organization of the cells into membraneless sub-compartments confers unique properties to cancer cells. The biochemical and biophysical mechanisms underpinning the formation of these compartments, also called biological condensates,… read more here.
Keywords: liquid phase; phase separation; liquid liquid; liquid ... See more keywords