Targeting PD-1 in cancer: Biological insights with a focus on breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.07.011
Abstract: Programmed cell death-1 (PD-1) receptor and its ligands physiologically regulate the activity of the adaptive immune system to limit excessive inflammatory processes, thus preventing normal tissue damage. Tumor cells escape from the host immune surveillance… read more here.
Keywords: targeting cancer; cancer biological; biological insights; breast cancer ... See more keywords
Quantum Chemical and Biological Insights into Redox Activity of Metallacarborane Complexes in Cancer Cells
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c00394
Abstract: A relationship between the electronic properties of metal ions in metallacarboranes and their ability to modulate mitochondrial oxidase activity and membrane hyperpolarization in cancer cells was demonstrated. Quantum chemistry methods, including DFT and molecular dynamics… read more here.
Keywords: cancer; cancer cells; chemical biological; biological insights ... See more keywords
MetaNetwork Enhances Biological Insights from Quantitative Proteomics Differences by Combining Clustering and Enrichment Analyses.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00756
Abstract: Interpreting proteomics data remains challenging due to the large number of proteins that are quantified by modern mass spectrometry methods. Weighted gene correlation network analysis (WGCNA) can identify groups of biologically related proteins using only… read more here.
Keywords: metanetwork enhances; insights quantitative; biological insights; metanetwork ... See more keywords
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
Sign Up to like & getrecommendations! Published in 2025 at "Communications Chemistry"
DOI: 10.1038/s42004-025-01665-1
Abstract: Plasma is a rich source of biomolecules, including proteins, that reflect both health and disease. Due to their key roles in biological processes, proteins hold significant potential as biomarkers, fueling the rise of plasma proteome… read more here.
Keywords: plasma; biomarker discovery; biological insights; plasma proteomics ... See more keywords
Chromatin accessibility: methods, mechanisms, and biological insights
Sign Up to like & getrecommendations! Published in 2022 at "Nucleus"
DOI: 10.1080/19491034.2022.2143106
Abstract: ABSTRACT Access to DNA is a prerequisite to the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and DNA repair. How the proteins that regulate these processes function in the context of… read more here.
Keywords: methods mechanisms; accessibility methods; accessibility; biological insights ... See more keywords
New Biological Insights on X and Y Chromosome-Bearing Spermatozoa
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00388
Abstract: A spermatozoon is a male germ cell capable of fertilizing an oocyte and carries genetic information for determining the sex of the offspring. It comprises autosomes and an X (X spermatozoa) or a Y chromosome… read more here.
Keywords: bearing spermatozoa; spermatozoa; biological insights; chromosome bearing ... See more keywords
Microbiome in cancer metastasis: biological insights and emerging spatial omics methods
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2025.1559870
Abstract: The role of the microbiome in cancer metastasis has emerged as a critical area of research, with growing evidence suggesting that microbial composition and interactions within the tumour microenvironment may significantly influence metastatic progression. This… read more here.
Keywords: cancer; biological insights; metastasis biological; microbiome cancer ... See more keywords
Physicochemical and Biological Insights Into the Molecular Interactions Between Extracellular DNA and Exopolysaccharides in Myxococcus xanthus Biofilms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.861865
Abstract: Extracellular DNA (eDNA) is a critical component in the extracellular matrix (ECM) of bacterial biofilms, while little is known about the mechanisms underlying how eDNA integrates into the ECM through potential macromolecular interactions. Myxococcus xanthus… read more here.
Keywords: dna; biological insights; physicochemical biological; myxococcus xanthus ... See more keywords
Novel Chemical and Biological Insights of Inositol Derivatives in Mediterranean Plants
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051525
Abstract: Inositols (Ins) are natural compounds largely widespread in plants and animals. Bio-sinthetically they derive from sugars, possessing a molecular structure very similar to the simple sugars, and this aspect concurs to define them as primary… read more here.
Keywords: biological insights; chemical biological; inositol derivatives; insights inositol ... See more keywords
Promising Chemotherapy for Malignant Pediatric Brain Tumor in Recent Biological Insights
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092685
Abstract: Brain tumors are the most widespread malignancies in children around the world. Chemotherapy plays a critical role in the treatment of these tumors. Although the current chemotherapy process has a remarkable outcome for a certain… read more here.
Keywords: promising chemotherapy; brain tumor; biological insights; brain ... See more keywords