Deep learning identifies explainable reasoning paths of mechanism of action for drug repurposing from multilayer biological network
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac469
Abstract: The discovery and repurposing of drugs require a deep understanding of the mechanism of drug action (MODA). Existing computational methods mainly model MODA with the protein-protein interaction (PPI) network. However, the molecular interactions of drugs… read more here.
Keywords: network; drug repurposing; biological network; deep learning ... See more keywords
MiMod: A New Algorithm for Mining Biological Network Modules
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DOI: 10.1109/access.2019.2909946
Abstract: It is fundamental to discover frequent network modules from multiple networks as they serve gene co-expression modules, biological pathways, or protein complexes. The rapid accumulation of biological network data has enabled the discovery of frequent… read more here.
Keywords: algorithm mining; biological network; frequent network; network modules ... See more keywords
NFP: An R Package for Characterizing and Comparing of Annotated Biological Networks
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/7457131
Abstract: Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts.… read more here.
Keywords: package; package characterizing; biological network; biological networks ... See more keywords
Ten simple rules to create biological network figures for communication
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007244
Abstract: Biological network figures are ubiquitous in the biology and medical literature. On the one hand, a good network figure can quickly provide information about the nature and degree of interactions between items and enable inferences… read more here.
Keywords: network; figures communication; simple rules; biological network ... See more keywords