Genes, Proteins, and Biological Pathways Preventing Chromothripsis.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7780-2_15
Abstract: The highly complex structural genome variations chromothripsis, chromoanasynthesis, and chromoplexy are subsumed under the term chromoanagenesis, which means chromosome rebirth. Precipitated by numerous DNA double-strand breaks, they differ in number of and distances between breakpoints,… read more here.
Keywords: biological pathways; chromothripsis; double strand; genes proteins ... See more keywords
MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114357
Abstract: Pancreatic Cancer (PC) is a severe form of malignancy all over the world. Delayed diagnosis and chemoresistance are the major factors contributing to its poor prognosis and high mortality rate. The genetic and epigenetic regulations… read more here.
Keywords: directly targeting; biological pathways; pancreatic cancer; mirnas directly ... See more keywords
The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.110039
Abstract: The omnipresence of antimicrobial triclosan (TCS) and by-products in aquatic environments is a threat to aquatic organisms. Traditionally, the adverse effects of TCS and its by-products have been evaluated by examining the phenotypic output relevant… read more here.
Keywords: tcs mtcs; biological pathways; metabolism; mtcs ... See more keywords
Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.08.003
Abstract: Recent work has demonstrated the importance of miRNAs in the pathogenesis of various brain disorders including the neurodegenerative disorder spinocerebellar ataxia (SCA). This review focuses on the role of miRNAs in the shared pathogenesis of… read more here.
Keywords: spinocerebellar ataxia; biological pathways; pervasive purkinje; purkinje cell ... See more keywords
Dystonia genes and their biological pathways
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.05.014
Abstract: The dystonias are a group of disorders characterized by excessive contraction of muscles leading to abnormal involuntary movements. The clinical manifestations are very heterogeneous, with numerous distinct syndromes. The etiologies for dystonia are also heterogeneous… read more here.
Keywords: dystonia genes; neurobiology; genes biological; biological pathways ... See more keywords
A genome-wide pathway enrichment analysis identifies brain region related biological pathways associated with intelligence
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.07.029
Abstract: Intelligence is an important quantitative trait associated with human cognitive ability. The genetic basis of intelligence remains unclear now. Utilizing the latest chromosomal enhancer maps of brain regions, we explored brain region related biological pathways… read more here.
Keywords: intelligence; biological pathways; brain regions; brain region ... See more keywords
Global analysis of inverted repeat sequences in human gene promoters reveals their non-random distribution and association with specific biological pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Genomics"
DOI: 10.1016/j.ygeno.2020.03.014
Abstract: Inverted repeats (IR) play important roles in specific DNA-dependent processes in simple prokaryotes to complex eukaryotes. They are recognized by a variety of proteins including restriction enzymes, helicases and transcription factors. We evaluate the presence… read more here.
Keywords: repeat sequences; biological pathways; global analysis; inverted repeat ... See more keywords
Evaluating the predictive accuracy of curated biological pathways in a public knowledgebase.
Sign Up to like & getrecommendations! Published in 2022 at "Database : the journal of biological databases and curation"
DOI: 10.1093/database/baac009
Abstract: ABSTRACT Reactome is a database of human biological pathways manually curated from the primary literature and peer-reviewed by experts. To evaluate the utility of Reactome pathways for predicting functional consequences of genetic perturbations, we compared… read more here.
Keywords: published empirical; biopath; pathway; accuracy ... See more keywords
A Scoping Review of Biological Pathways of Integrative Interventions Used to Manage Chemotherapy-Induced Nausea and Vomiting in Children With Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Nursing Research"
DOI: 10.1097/nnr.0000000000000579
Abstract: Background As with pharmacological management approaches, characteristics of complementary and alternative medicine (CAM) interventions for managing chemotherapy-induced nausea and vomiting (CINV) in children with cancer should be considered when developing and testing these interventions and… read more here.
Keywords: cam interventions; biological pathways; scoping review; integrative interventions ... See more keywords
A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation
Sign Up to like & getrecommendations! Published in 2017 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000478698
Abstract: Background: Nonallergic vasomotor rhinitis (NAVMR) has been considered a diagnosis by exclusion due to unknown mechanisms or lack of diagnostic biomarkers. Methods: To determine clinical responses and biological pathways in NAVMR subjects challenged to cold… read more here.
Keywords: cda; biological pathways; vasomotor rhinitis; visit ... See more keywords
Topology and redescriptions detect multiple alternative biological pathways from clinical phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221126671
Abstract: Biological pathways play a crucial role in the properties of diseases and are important in drug discovery. Identifying the logical relationships among distinctive phenotypic clusters could reveal possible connections to the underlying pathways. However, this… read more here.
Keywords: topology; clinical notes; topology redescriptions; clinical phenotypes ... See more keywords