Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00248
Abstract: Recently, a new suite of mass spectrometry-based proteomic methods has been developed that enables evaluation of protein folding stability on the proteomic scale. These methods utilize chemical and thermal denaturation approaches (SPROX and TPP, respectively)… read more here.
Keywords: protein folding; folding stability; analysis; biological phenotypes ... See more keywords
Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis
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DOI: 10.1097/eja.0000000000000846
Abstract: BACKGROUND Biological phenotypes have been identified within several heterogeneous pulmonary diseases, with potential therapeutic consequences. OBJECTIVE To assess whether distinct biological phenotypes exist within surgical patients, and whether development of postoperative pulmonary complications (PPCs) and… read more here.
Keywords: biological phenotypes; cluster analysis; pre operative; analysis ... See more keywords
Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis
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DOI: 10.1136/thoraxjnl-2016-209719
Abstract: Rationale We hypothesised that patients with acute respiratory distress syndrome (ARDS) can be clustered based on concentrations of plasma biomarkers and that the thereby identified biological phenotypes are associated with mortality. Methods Consecutive patients with… read more here.
Keywords: biological phenotypes; validation; patients acute; mortality ... See more keywords