Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2H)‐ones as anti‐inflammatory and analgesic agents
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900295
Abstract: Some novel derivatives of 2‐alkyl 6‐substituted pyridazin‐3(2H)‐ones were synthesized by condensation of 3,6‐dichloropyridazine with the sodium salt of benzyl cyanide, followed by hydrolysis and coupling with alkyl halides. The synthesized compounds were screened as cyclooxygenase… read more here.
Keywords: anti inflammatory; biological screening; novel substituted; substituted alkylpyridazin ... See more keywords
Synthesis and biological screening of a novel enaminone-grafted trithiocarbonate: a potential anticancer and antimicrobial agent
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02535-2
Abstract: A need exists to develop safe and efficacious medications to treat major diseases such as cancer and infectious diseases. In response to this need, we synthesized a novel enaminone, which structurally belongs to the trithiocarbonate… read more here.
Keywords: biological screening; screening novel; novel enaminone; synthesis biological ... See more keywords
Synthesis, characterization, in silico, and in vitro biological screening of coordination compounds with 1,2,4-triazine based biocompatible ligands and selected 3d-metal ions
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DOI: 10.1016/j.heliyon.2020.e05144
Abstract: A bidentate Schiff base ligand, MHMMT, obtained from 1,2,4-triazine derivative and 4-hydroxy-3-methoxy benzaldehyde and its Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesised in ethanolic media and characterized by various analytical techniques like elemental… read more here.
Keywords: biological screening; silico vitro; vitro biological; characterization silico ... See more keywords
Synthesis and biological screening of some chromonyl-substituted heterocycles derived from 2(3H)-furanone derivative
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DOI: 10.1080/00397911.2016.1271896
Abstract: ABSTRACT A 2(3H)-furanone bearing chromonyl moiety at position-3 was synthesized and utilized for the construction of N-heterocycles such as pyrrolone, N-aminoquinolone, and pyridazinone derivatives. The reactivity of the chromonylfuranone toward some nitrogen nucleophiles such as… read more here.
Keywords: chromonyl substituted; biological screening; screening chromonyl; substituted heterocycles ... See more keywords
Design, Synthesis, and Biological Screening for Cytotoxic Activity of Monastrol Analogues
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DOI: 10.1080/10406638.2021.1913424
Abstract: A series of 1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives was synthesized through one-pot condensation reaction; it was confirmed via NMR, FTIR, MS spectra, and element analysis. Then, the... read more here.
Keywords: design synthesis; biological screening; activity monastrol; screening cytotoxic ... See more keywords
Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
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DOI: 10.3390/biom13040694
Abstract: PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented… read more here.
Keywords: biological screening; phosphorylation; ppar phosphorylation; hydroxy lactone ... See more keywords