Identification of biological targets through the correlation between cell line chemosensitivity and protein expression pattern.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.05.013
Abstract: Matching biological data sequences is one of the most interesting ways to discover new bioactive compounds. In particular, matching cell chemosensitivity with a protein expression profile can be a useful approach to predict the activity… read more here.
Keywords: protein expression; expression; chemosensitivity protein; biological targets ... See more keywords
Different Reaction Specificities of F420H2-Dependent Reductases Facilitate Pyrrolobenzodiazepines and Lincomycin to Fit Their Biological Targets.
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DOI: 10.1021/jacs.9b11234
Abstract: Lincosamide antibiotics, antitumor pyrrolobenzodiazepines (PBDs), quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and functionally diverse groups of actinobacterial metabolites. The common feature of these metabolites is the incorporation of L-tyrosine- or L-leucine-derived 4-alkyl-L-proline derivatives… read more here.
Keywords: different reaction; reaction specificities; f420h2 dependent; biological targets ... See more keywords
Thymol and carvacrol derivatives as anticancer agents; synthesis, in vitro activity, and computational analysis of biological targets
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DOI: 10.1039/d4ra03941f
Abstract: Various thymol and carvacrol derivatives have been synthesized to test the anticancer activity potential. Computational methods including network pharmacology and molecular docking approaches were utilized to identify and assess the potential biological targets relating to… read more here.
Keywords: thymol carvacrol; biological targets; computational analysis; carvacrol derivatives ... See more keywords
DRUDIT: web-based DRUgs DIscovery Tools to design small molecules as modulators of biological targets
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DOI: 10.1093/bioinformatics/btz783
Abstract: MOTIVATION New in silico tools to predict biological affinities for input structures are presented. The tools are implemented in the DRUDIT (DRUgs DIscovery Tools) web service. The DRUDIT biological finder module is based on molecular… read more here.
Keywords: drudit; discovery tools; target; drugs discovery ... See more keywords
Biological Targets for Dupuytren Disease
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DOI: 10.1097/sap.0000000000002739
Abstract: Abstract Dupuytren disease is a connective tissue disorder occurring on the palm, causing flexion contractures of fingers. There is a pressing need for therapeutic interventions that can slow, stop, or even incrementally reverse the progression… read more here.
Keywords: biological targets; targets dupuytren; growth; dupuytren disease ... See more keywords