A Biologically Informed Vision-Guided Framework for Interpretable T Cell Receptor-Epitope Binding Prediction.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512544
Abstract: Accurate identification of the interactions between T‐cell receptors (TCRs) and antigenic epitopes presented by major histocompatibility complex (MHC) molecules is fundamental to advancing cancer immunotherapy. Nevertheless, predictive modeling of TCR–epitope binding remains challenging, as existing… read more here.
Keywords: vision guided; biologically informed; informed vision; epitope binding ... See more keywords
Utility of multi-omics data to inform genomic prediction of heifer fertility traits.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac340
Abstract: Biologically informed single nucleotide polymorphisms (SNP) impact genomic prediction accuracy of the target traits. Our previous genomics, proteomics, and transcriptomics work identified candidate genes related to puberty and fertility in Brahman heifers. We aimed to… read more here.
Keywords: fertility traits; snp; prediction; snp set ... See more keywords
FR-BINN: Biologically Informed Neural Networks for Enhanced Biomarker Discovery and Pathway Analysis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26146670
Abstract: Chronic inflammation plays a pivotal role in human health, with certain inflammatory conditions significantly increasing the risk of cancer, while others do not. However, the molecular mechanisms underlying this divergent risk remain poorly understood. In… read more here.
Keywords: cancer; biologically informed; binn biologically; informed neural ... See more keywords