A synthetic biology approach for the fabrication of functional (fluorescent magnetic) bioorganic–inorganic hybrid materials in sponge primmorphs
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27310
Abstract: During evolution, sponges (Porifera) have honed the genetic toolbox and biosynthetic mechanisms for the fabrication of siliceous skeletal components (spicules). Spicules carry a protein scaffold embedded within biogenic silica (biosilica) and feature an amazing range… read more here.
Keywords: hybrid materials; biology approach; synthetic biology; biology ... See more keywords
Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8728-3_15
Abstract: Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity and… read more here.
Keywords: biology approach; causal; biology; systems biology ... See more keywords
Systems biology approach identifies key genes and related pathways in childhood obesity.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146512
Abstract: BACKGROUND Childhood obesity is triggered by a complex interplay of environmental, genetic, and epigenetic factors; however, the molecular mechanisms behind this disease are not completely elucidated. Thus, the aim of this study was to investigate… read more here.
Keywords: childhood obesity; biology; obesity; biology approach ... See more keywords
Systems Biology Approach Pinpoints Minimum Requirements for Auxin Distribution during Fruit Opening
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Plant"
DOI: 10.1016/j.molp.2019.05.003
Abstract: The phytohormone auxin is implied in steering various developmental decisions during plant morphogenesis in a concentration-dependent manner. Auxin maxima have been shown to maintain meristematic activity, for example, of the root apical meristem, and position… read more here.
Keywords: auxin minimum; biology approach; fruit; biology ... See more keywords
Reconstitution of an Ultradian Oscillator in Mammalian Cells by a Synthetic Biology Approach.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00083
Abstract: The Notch effector gene Hes1 is an ultradian clock exhibiting cyclic gene expression in several progenitor cells, with a period of a few hours. Because of the complexity of studying Hes1 in the endogenous setting,… read more here.
Keywords: ultradian oscillator; synthetic biology; biology; biology approach ... See more keywords
Integrative analysis of Multiple Sclerosis using a systems biology approach
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24032-8
Abstract: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory-demyelinating events in the central nervous system. Despite more than 40 years of MS research its aetiology remains unknown. This study aims to identify the… read more here.
Keywords: biology approach; analysis; multiple sclerosis; biology ... See more keywords
ANP32E, a Protein Involved in Steroid-Refractoriness in Ulcerative Colitis, Identified by a Systems Biology Approach
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy171
Abstract: BACKGROUND AND AIMS Steroid-refractoriness is a common and unpredictable phenomenon in ulcerative colitis [UC], but there are no conclusive studies on the molecular functions involved. We aimed to assess the mechanism of action related to… read more here.
Keywords: biology approach; steroid refractoriness; biology; approach ... See more keywords
A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm2510
Abstract: Despite the availability of highly efficacious vaccines, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lacks effective drug treatment, which results in a high rate of mortality. To address this… read more here.
Keywords: ill patients; biology approach; systems biology; reduce mortality ... See more keywords
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm6376
Abstract: A number of neurodegenerative conditions are associated with the formation of cytosolic inclusions of TDP-43 within neurons. We expressed full-length TDP-43 in a motoneuron/neuroblastoma hybrid cell line (NSC-34) and exploited the high-resolution power of stimulated… read more here.
Keywords: quantitative biology; biology approach; inclusions tdp; microscopy ... See more keywords
Systematic Review of Existing Stroke Guidelines: Case for a Change
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5514793
Abstract: Methods We systematically searched for guideline recommendation on the day-to-day use of peripheral inflammatory markers such as NLR published in the English language between January 1, 2005, and October 2020. Any other evidence of system… read more here.
Keywords: stroke guidelines; biology approach; biology; systematic review ... See more keywords
A systems biology approach for studying Wolbachia metabolism reveals points of interaction with its host in the context of arboviral infection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007678
Abstract: Wolbachia are alpha-proteobacteria known to infect arthropods, which are of interest for disease control since they have been associated with improved resistance to viral infection. Although several genomes for different strains have been sequenced, there… read more here.
Keywords: biology approach; metabolism; infection; biology ... See more keywords