Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy.
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DOI: 10.1016/j.biotechadv.2017.05.004
Abstract: Ubiquitous Chromatin-opening Elements (UCOEs) are defined by their ability to consistently confer stable, site of integration-independent transgene expression that is proportional to copy number, including from within regions of heterochromatin such as centromeres. UCOEs structurally… read more here.
Keywords: opening elements; ubiquitous chromatin; chromatin opening; gene ... See more keywords