Finding the (biomarker-defined) subgroup of patients who benefit from a novel therapy: No time for a game of hide and seek.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical trials"
DOI: 10.1177/17407745231169692
Abstract: An important element of precision medicine is the ability to identify, for a specific therapy, those patients for whom benefits of that therapy meaningfully exceed the risks. To achieve this goal, treatment effect usually is… read more here.
Keywords: treatment effect; biomarker defined; biomarker; therapy ... See more keywords
Biomarker-Defined Subsets of Common Diseases: Policy and Economic Implications of Orphan Drug Act Coverage
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1002190
Abstract: Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. read more here.
Keywords: diseases policy; biomarker defined; common diseases; defined subsets ... See more keywords