Challenges and Opportunities in State-of-the-Art Proteomics Analysis for Biomarker Development From Plasma Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2025 at "Proteomics"
DOI: 10.1002/pmic.70036
Abstract: Extracellular vesicles (EVs) are membrane-bound particles secreted by cells, playing crucial roles in intercellular communication. The composition of EVs can undergo changes in response to stress and disease conditions, making them excellent biomarker candidates. However,… read more here.
Keywords: extracellular vesicles; challenges opportunities; opportunities state; biomarker development ... See more keywords
Alzheimer's disease biomarker development: a call to funding bodies
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.02.035
Abstract: Biomarkers can be regarded as highly objective, quantifiable, and reproducible medical signs, that is, “objective indications of medical state observed from outside the patientdin contrast to medical symptoms, which are perceived by patients themselves” (Strimbu… read more here.
Keywords: biomarker research; alzheimer disease; biomarker; disease ... See more keywords
Preanalytic and Analytic Quality System Considerations in Noncoding RNA Biomarker Development for Clinical Diagnostics.
Sign Up to like & getrecommendations! Published in 2023 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2022.0086
Abstract: A frequent topic of biomedical research is the potential clinical use of non-coding (nc) RNAs as quantitative biomarkers for a broad spectrum of health and disease. However, ncRNA analyses have not been pressed into widespread… read more here.
Keywords: biomarker; biomarker development; analytic quality; quality system ... See more keywords
Abstract 4815: Humanized single mouse trial: A preclinical platform feasible for immune-oncology drug screening and translational biomarker development
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4815
Abstract: The field of cancer immunology is rapidly moving towards innovative therapeutic strategies. As a consequence the need for robust and predictive preclinical platforms arises just as well. The current project aims to establish a drug… read more here.
Keywords: treatment; single mouse; drug screening; biomarker development ... See more keywords
Biomarker development in Sturge-Weber syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurodevelopmental Disorders"
DOI: 10.1186/s11689-025-09640-6
Abstract: Sturge-Weber Syndrome (SWS) is a congenital neurovascular disorder caused by a somatic mosaic mutation in the R183Q GNAQ gene and characterized by capillary-venous malformations of the brain, skin, and eyes. Clinical manifestations include facial port-wine… read more here.
Keywords: sturge weber; development sturge; weber syndrome; biomarker development ... See more keywords
Enhancing sepsis biomarker development: key considerations from public and private perspectives
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DOI: 10.1186/s13054-024-05032-9
Abstract: Implementation of biomarkers in sepsis and septic shock in emergency situations, remains highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to facilitate the transition of sepsis biomarkers into clinical practice. The authors… read more here.
Keywords: public private; sepsis biomarker; biomarker development; biomarker ... See more keywords
Disease modification and biomarker development in Parkinson disease
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DOI: 10.1212/wnl.0000000000009107
Abstract: A fundamental question in advancing Parkinson disease (PD) research is whether it represents one disorder or many. Does each genetic PD inform a common pathobiology or represent a unique entity? Do the similarities between genetic… read more here.
Keywords: biomarker development; modification biomarker; disease modification; parkinson disease ... See more keywords
Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.890638
Abstract: Proteomics studies have shown differential expression of numerous proteins in dementias but have rarely led to novel biomarker tests for clinical use. The Marie Curie MIRIADE project is designed to experimentally evaluate development strategies to… read more here.
Keywords: miriade; multi omics; biomarker; biomarker development ... See more keywords