Application of Lectin Microarrays for Biomarker Discovery
Sign Up to like & getrecommendations! Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.201900326
Abstract: Abstract Many proteins in living organisms are glycosylated. As their glycan patterns exhibit protein‐, cell‐, and tissue‐specific heterogeneity, changes in the glycosylation levels could serve as useful indicators of various pathological and physiological states. Thus,… read more here.
Keywords: biomarker discovery; microarrays biomarker; lectin; lectin microarrays ... See more keywords
Opportunities for pharmacoproteomics in biomarker discovery
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200031
Abstract: Proteomic data are a uniquely valuable resource for drug response prediction and biomarker discovery because most drugs interact directly with proteins in target cells rather than with DNA or RNA. Recent advances in mass spectrometry… read more here.
Keywords: pharmacoproteomics biomarker; biomarker discovery; drug; discovery ... See more keywords
Progress and Potential of Imaging Mass Spectrometry Applied to Biomarker Discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6952-4_2
Abstract: Mapping provides a direct means to assess the impact of protein biomarkers and puts into context their relevance in the type of cancer being examined. To this end, mass spectrometry imaging (MSI) was developed to… read more here.
Keywords: biomarker discovery; progress; mass; mass spectrometry ... See more keywords
Metabolomics Toward Biomarker Discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7057-5_32
Abstract: Metabolomics has been used as practical tool in the discovery of novel biomarkers in a broad area in the clinic. The analytical platforms including nuclear magnetic resonance (NMR) and mass spectrometry (MS) can cover thousands… read more here.
Keywords: biomarker discovery; discovery; biology; metabolomics toward ... See more keywords
Biomarker Discovery Using NMR-Based Metabolomics of Tissue.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9690-2_15
Abstract: NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic profiles from intact tissue specimens can be obtained with… read more here.
Keywords: biomarker discovery; tissue; metabolomics tissue; based metabolomics ... See more keywords
Innovative methods for biomarker discovery in the evaluation and development of cancer precision therapies
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9710-0
Abstract: The discovery of biomarkers able to detect cancer at an early stage, to evaluate its aggressiveness, and to predict the response to therapy remains a major challenge in clinical oncology and precision medicine. In this… read more here.
Keywords: biomarker discovery; methods biomarker; innovative methods; development cancer ... See more keywords
Biomarker Discovery in Parkinson’s Disease: Present Challenges and Future Opportunities
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-017-0184-4
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the substantia nigra and cytoplasmic… read more here.
Keywords: biomarker discovery; disease present; diagnosis; discovery parkinson ... See more keywords
High-throughput and high-sensitivity N-Glycan profiling: a platform for biopharmaceutical development and disease biomarker discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114205
Abstract: Protein glycosylation contributes to critical biological function of glycoproteins. Glycan analysis is essential for the production of biopharmaceuticals as well as for the identification of biomarkers of disease. However, glycans are highly heterogeneous, which has… read more here.
Keywords: glycan profiling; biomarker discovery; high sensitivity; biopharmaceutical development ... See more keywords
Mechanism-based biomarker discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.04.013
Abstract: Biomarkers are cornerstones of healthcare spanning a wide spectrum of applications like disease diagnosis and stratification of patient populations. Despite significant efforts that have identified thousands of potential biomarkers, their translation into clinical practice remains… read more here.
Keywords: mechanism based; biomarker; biomarker discovery; based biomarker ... See more keywords
Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.104001
Abstract: Summary Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the poorest prognosis among gynecological malignancies. Because of the absence of specific early symptoms, most OC patients are often diagnosed at… read more here.
Keywords: ovarian cancer; omics approaches; multi omics; approaches biomarker ... See more keywords
Immunological Biomarker Discovery in Cure Regimens for Chronic Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.02.020
Abstract: There have been unprecedented advances in identifying new targets for chronic hepatitis B therapy to achieve functional cure in patients who would otherwise face lifelong nucleoside analogue treatment. Many of the new investigational therapies either… read more here.
Keywords: chronic hepatitis; clinical trials; immunological biomarker; biomarker discovery ... See more keywords