Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26913
Abstract: Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach… read more here.
Keywords: medicine; parkinson; disease modifying; disease ... See more keywords
Biomarker-driven drug repurposing on biologically similar cancers with DNA-repair deficiencies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1015531
Abstract: Similar molecular and genetic aberrations among diseases can lead to the discovery of jointly important treatment options across biologically similar diseases. Oncologists closely looked at several hormone-dependent cancers and identified remarkable pathological and molecular similarities… read more here.
Keywords: dna repair; biomarker driven; biologically similar; drug repurposing ... See more keywords