Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26913
Abstract: Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach… read more here.
Keywords: medicine; parkinson; disease modifying; disease ... See more keywords
Biomarker-driven basket trial designs: origins and new methodological developments
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2024.2358806
Abstract: ABSTRACT Due to increased use of gene sequencing techniques, understanding of cancer on a molecular level has evolved, in terms of both diagnosis and evaluation in response to initial therapies. In parallel, clinical trials meant… read more here.
Keywords: basket; basket trial; driven basket; biomarker driven ... See more keywords
Biomarker-driven optimal designs for patient enrollment restriction
Sign Up to like & getrecommendations! Published in 2025 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802251327690
Abstract: The rapidly developing field of personalized medicine is giving the opportunity to treat patients with a specific regimen according to their individual demographic, biological, or genomic characteristics, known also as biomarkers. While binary biomarkers simplify… read more here.
Keywords: patient enrollment; driven optimal; designs patient; biomarker driven ... See more keywords
Personalized biomarker-based treatment strategy in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: Results of the biomarker-driven cohorts of the EORTC-HNCG-1559 trial (UPSTREAM).
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.6028
Abstract: 6028 Background: Platinum-refractory recurrent/metastatic squamous cell carcinoma (R/M SCCHN) has a poor prognosis. Several molecular pathways are dysregulated in SCCHN, providing potential targets for treatment. The UPSTREAM trial aimed to develop a personalized treatment strategy… read more here.
Keywords: cohort; treatment; trial; driven cohorts ... See more keywords
Biomarker-driven drug repurposing on biologically similar cancers with DNA-repair deficiencies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1015531
Abstract: Similar molecular and genetic aberrations among diseases can lead to the discovery of jointly important treatment options across biologically similar diseases. Oncologists closely looked at several hormone-dependent cancers and identified remarkable pathological and molecular similarities… read more here.
Keywords: dna repair; biomarker driven; biologically similar; drug repurposing ... See more keywords