Amyloid-β Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-β Positivity
Sign Up to like & getrecommendations! Published in 2020 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2019.12.021
Abstract: BACKGROUND Stage 1 of the National Institute on Aging-Alzheimer's Association's proposed Alzheimer's disease continuum is defined as amyloid-β (Aβ) positive but cognitively normal. Identifying at-risk individuals before Aβ reaches pathological levels could have great benefits… read more here.
Keywords: amyloid positivity; positivity; biomarker levels; baseline ... See more keywords
Variation in biomarker levels of metals, persistent organic pollutants, and omega-3 fatty acids in association with genetic polymorphisms among Inuit in Nunavik, Canada.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental research"
DOI: 10.1016/j.envres.2021.111393
Abstract: BACKGROUND Biomarker measures of contaminant exposure and nutrient status can help increase understanding of the risks and benefits associated with the consumption of traditional foods by Inuit. While gene-environment and gene-nutrient interactions may help explain… read more here.
Keywords: among inuit; genetic polymorphisms; biomarker; biomarker levels ... See more keywords
Biomarker genetics
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-021-00400-y
Abstract: Biomarkers are often used to diagnose and monitor chronic diseases, and greater understanding of how genetic variants associate with biomarker levels has potential to aid risk stratification and identify new therapeutic targets. an analysis of… read more here.
Keywords: risk; biomarker; biobank; genetics ... See more keywords
Obesity affects type 2 biomarker levels in asthma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2051548
Abstract: Abstract Objective Type 2 (T2) inflammation offers a therapeutic target for biologics. Previous trials suggest obesity influences T2-biomarker levels in asthma, though have not accounted for key variables, e.g. inhaled (ICS)/oral corticosteroid (OCS) use. We… read more here.
Keywords: levels asthma; biomarker; tertile; bmi ... See more keywords
Genetic factors associated with age-related macular degeneration modulating plasma inflammatory biomarker levels in patients with AIDS
Sign Up to like & getrecommendations! Published in 2024 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2024.2330380
Abstract: ABSTRACT Introduction Patients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in… read more here.
Keywords: related macular; age related; inflammatory biomarker; biomarker levels ... See more keywords
Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004316
Abstract: Supplemental Digital Content is available in the text. Objectives: The 2015 definition for pediatric acute respiratory distress syndrome did not require the presence of bilateral infiltrates. We tested the hypothesis that pediatric patients meeting oxygenation… read more here.
Keywords: inflammatory biomarker; biomarker levels; bilateral infiltrates; oxygenation defect ... See more keywords
A retrospective observational study of biomarker levels and severity assessment in pediatric community-acquired pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030010
Abstract: Multiple studies have investigated the role of biomarkers in predicting pneumonia severity in adults but minimal conclusive research exists for children. This study aimed to determine if the following biomarker levels, collected within 72 hours… read more here.
Keywords: severity assessment; cap; moderate severe; severity ... See more keywords
Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Science"
DOI: 10.1111/cts.12625
Abstract: Understanding transporter‐mediated drug–drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)‐I, and CP‐III as clinical biomarkers for evaluating organic anion‐transporting… read more here.
Keywords: biomarker; healthy volunteers; drug; biomarker levels ... See more keywords
Circulating biomarkers and progression of idiopathic pulmonary fibrosis: data from the INMARK trial
Sign Up to like & getrecommendations! Published in 2024 at "ERJ Open Research"
DOI: 10.1183/23120541.00335-2023
Abstract: Background We used data from the INMARK trial to investigate associations between circulating biomarkers of extracellular matrix (ECM) turnover, inflammation and epithelial dysfunction and disease progression in subjects with idiopathic pulmonary fibrosis (IPF). Methods Subjects… read more here.
Keywords: idiopathic pulmonary; demographic clinical; progression; pulmonary fibrosis ... See more keywords
Biomarker Levels of Toxic Metals among Asian Populations in the United States: NHANES 2011–2012
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Health Perspectives"
DOI: 10.1289/ehp27
Abstract: Introduction: The Centers for Disease Control and Prevention (CDC) recently found that Asians have considerably higher biomarker levels of cadmium, lead, mercury, and arsenic than whites, blacks, Mexican Americans, and other Hispanics in the United… read more here.
Keywords: asian subgroups; biomarker; levels toxic; biomarker levels ... See more keywords
Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.700636
Abstract: Isocyanates are respiratory and skin sensitizers that are one of the main causes of occupational asthma globally. Genetic and epigenetic markers are associated with isocyanate-induced asthma and, before asthma develops, we have shown that genetic… read more here.
Keywords: epigenetic markers; biomarker; spray painters; biomarker levels ... See more keywords