CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Immunology Research"
DOI: 10.1155/2020/9435030
Abstract: CD47 is a cell surface protein in the immunoglobulin superfamily which is normally expressed at low levels in every healthy cell. It´s main physiologic function is to act as an inhibitor of phagocytosis; this occurs… read more here.
Keywords: biomarker therapeutic; cd47; nonsmall cell; target cancer ... See more keywords
MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020005795
Abstract: Multiple myeloma (MM) remains largely incurable despite significant advances in bio- and chemotherapy. The major problem in MM management is development of drug resistance. Macrophage migration inhibitory factor (MIF) expression was significantly higher in purified… read more here.
Keywords: biomarker therapeutic; myeloma; mif biomarker; resistance ... See more keywords
MiR-4763-3p targeting RASD2as a Potential Biomarker and Therapeutic Target for Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2022.0103
Abstract: Existing diagnostic methods are limited to observing appearance and demeanor, even though genetic factors play important roles in the pathology of schizophrenia. Indeed, no molecular-level test exists to assist diagnosis, which has limited treatment strategies.… read more here.
Keywords: therapeutic target; mir 4763; biomarker therapeutic; potential biomarker ... See more keywords
CD38 a biomarker and therapeutic target in non-hematopoietic tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0575
Abstract: The type II transmembrane glycoprotein CD38 has recently been implicated in regulating metabolism and the pathogenesis of multiple conditions, including aging, inflammation and cancer. CD38 is overexpressed in several tumor cells and microenvironment tumoral cells,… read more here.
Keywords: therapeutic target; cd38 biomarker; biomarker therapeutic; target non ... See more keywords
LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.785030
Abstract: Long non-coding RNAs (lncRNAs) are a class of functional RNA molecules that do not encode proteins and are composed of more than 200 nucleotides. LncRNAs play important roles in epigenetic and gene expression regulation. The… read more here.
Keywords: therapeutic target; lncrna gacat3; biomarker therapeutic; promising biomarker ... See more keywords
circRNA: A New Biomarker and Therapeutic Target for Esophageal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071643
Abstract: Circular RNAs (circRNAs) comprise a large class of endogenous non-coding RNA with covalently closed loops and have independent functions as linear transcripts transcribed from identical genes. circRNAs are generated by a “back-splicing” process regulated by… read more here.
Keywords: therapeutic target; esophageal cancer; biomarker therapeutic; circrna new ... See more keywords
Autoantibodies as Biomarker and Therapeutic Target in Systemic Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092150
Abstract: Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by immune dysregulation evoking the pathophysiological triad of inflammation, fibrosis and vasculopathy. In SSc, several alterations in the B-cell compartment have been described, leading to… read more here.
Keywords: therapeutic target; systemic sclerosis; target systemic; sclerosis ... See more keywords
Hitting the Bull’s-Eye: Mesothelin’s Role as a Biomarker and Therapeutic Target for Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13163932
Abstract: Simple Summary Mesothelioma is a deadly disease with a dismal prognosis. Since its discovery, mesothelin, a cell surface protein, has been a promising biomarker and therapeutic target due to its overexpression in mesothelioma and limited… read more here.
Keywords: mpm; biomarker therapeutic; mesothelioma; target ... See more keywords
A Promising Biomarker and Therapeutic Target in Patients with Advanced PDAC: The Stromal Protein βig-h3
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040623
Abstract: With an overall survival rate of 2–9% at 5 years, pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of cancer-related deaths in the industrialized world and is predicted to become the second by… read more here.
Keywords: therapeutic target; stromal protein; biomarker therapeutic; promising biomarker ... See more keywords
Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oncology"
DOI: 10.3892/ijo.2017.4181
Abstract: Oral cancer has a high mortality rate, and its incidence is increasing gradually worldwide. As the effectiveness of standard treatments is still limited, the development of new therapeutic strategies is eagerly awaited. Kinesin family member… read more here.
Keywords: biomarker therapeutic; oral cancer; cancer; therapeutic target ... See more keywords
Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2022.5317
Abstract: Oral cancer is a leading cause of cancer‑related death worldwide. Current treatment for oral cancer includes surgery, radiotherapy, and chemotherapy; however, their effectiveness is still limited. To identify a new prognostic biomarker and therapeutic target… read more here.
Keywords: therapeutic target; oral cancer; biomarker therapeutic; target oral ... See more keywords