Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00807
Abstract: Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson’s disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either… read more here.
Keywords: pharmacodynamic biomarkers; biomarkers emerging; biomarker; lrrk2 therapeutics ... See more keywords
Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031665
Abstract: Triple-negative breast cancer (TNBC) is associated with high recurrence rates, high incidence of distant metastases, and poor overall survival (OS). Taxane and anthracycline-containing chemotherapy (CT) is currently the main systemic treatment option for TNBC, while… read more here.
Keywords: mechanisms biomarkers; emerging therapies; biomarkers emerging; molecular mechanisms ... See more keywords
Novel biomarkers and emerging tools to identify causal molecular pathways in hypertension and associated cardiovascular diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Kardiologia polska"
DOI: 10.33963/kp.a2023.0037
Abstract: Hypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases (CVDs) including coronary artery disease, heart failure or stroke. Despite significant progress in understanding of the pathophysiological mechanisms of the disease, the molecular pathways… read more here.
Keywords: novel biomarkers; hypertension; biomarkers emerging; cardiovascular diseases ... See more keywords