Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Medicine"
DOI: 10.1007/s11684-018-0678-0
Abstract: Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as… read more here.
Keywords: checkpoint inhibitors; biomarkers immunotherapy; monitoring checkpoint; inhibitors predictive ... See more keywords
Biomarkers for immunotherapy in urological cancers
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000000465
Abstract: Purpose of review Immunotherapies for urological malignancies have made tremendous progress by targeting immune checkpoints and have been implemented in clinical practice nowadays. Though siginifcant number of patients does not respond to immunotherapy. Biomarkers could… read more here.
Keywords: urology; immunotherapy urological; urological cancers; biomarkers immunotherapy ... See more keywords
Myeloid Resistance is not Futile: Biomarkers of Immunotherapy in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-1011
Abstract: The majority of patients with urothelial cancer do not respond to immune checkpoint blockade directed at the PD-(L)1 axis. Recently, robust profiling data were used to derive predictive biomarker signatures for both protumorigenic immunity and… read more here.
Keywords: myeloid resistance; resistance futile; immunotherapy bladder; futile biomarkers ... See more keywords
Combining Biomarkers for Immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2018-143
Abstract: A biomarker analysis involving the largest dataset of its kind finds that tumor mutational burden and T cell-inflamed gene expression profile can independently predict a patient's response to pembrolizumab. However, joint consideration of both biomarkers… read more here.
Keywords: biomarkers immunotherapy; biology; combining biomarkers;
Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.
Sign Up to like & getrecommendations! Published in 2020 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2020-0310
Abstract: In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting… read more here.
Keywords: future perspectives; biomarkers immunotherapy; efficacy; efficacy non ... See more keywords
Advanced development of biomarkers for immunotherapy in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1091088
Abstract: Hepatocellular carcinoma (HCC) is the most common liver cancer and one of the leading causes of cancer-related deaths in the world. Mono-immunotherapy and combination therapy with immune checkpoint inhibitors (ICIs) and multitargeted tyrosine kinase inhibitors… read more here.
Keywords: hepatocellular carcinoma; hcc; advanced development; biomarkers immunotherapy ... See more keywords
Biomarkers for Immunotherapy in Poorly Differentiated Sinonasal Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092205
Abstract: The sinonasal cavities harbor a wide variety of rare cancer types. Histopathological classification can be challenging, especially for poorly differentiated tumors. Despite advances in surgery and radio-chemotherapy, the 5-year survival rate is still very low.… read more here.
Keywords: differentiated sinonasal; sinonasal tumors; biomarkers immunotherapy; poorly differentiated ... See more keywords
Emerging Biomarkers for Immunotherapy in Glioblastoma
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DOI: 10.3390/cancers14081940
Abstract: Simple Summary Immunotherapy has shown clinical benefits in several solid cancers; still, glioblastoma remains very challenging to treat. Glioblastoma is the most frequent brain cancer and displays great heterogeneity. The standard of care has remained… read more here.
Keywords: emerging biomarkers; immunotherapy; cancer; biomarkers immunotherapy ... See more keywords
Present and Emerging Biomarkers in Immunotherapy for Metastatic Non-Small Cell Lung Cancer: A Review
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DOI: 10.3390/curroncol29020043
Abstract: Targeting the immune system, especially the PDL-1/PD-1 axis, has significantly improved the outcomes of metastatic lung cancer patients. However, only a portion of patients will benefit significantly from PD(L)1 therapeutics alone or in combination with… read more here.
Keywords: lung cancer; present emerging; lung; biomarkers immunotherapy ... See more keywords