Multiple biomarkers response in a Neotropical fish exposed to paralytic shellfish toxins (PSTs).
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.124616
Abstract: The Alagados Reservoir (Southern Brazil) is used as water supply, and since 2002 there have been reports with a presence of cyanobacterial blooms and cyanotoxins. In order to assess the water quality and the ecological… read more here.
Keywords: biomarkers response; multiple biomarkers; alagados reservoir; response neotropical ... See more keywords
Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-019-0521-7
Abstract: The identification of biomarkers of response might speed drug development and set the premises to assist clinical practice in psychiatry. In this work, we evaluated a panel of peripheral biomarkers (including IL-6, IL-10, TNF-α, TNFRII,… read more here.
Keywords: response; biomarkers response; venlafaxine; two randomised ... See more keywords
Predictive biomarkers of response to immune checkpoint inhibitors in melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2020.1724539
Abstract: ABSTRACT Introduction: Advanced melanoma has recently been transformed by the advent of immune checkpoint inhibitors. These agents have altered the prognosis of this disease from a median survival of read more here.
Keywords: immune checkpoint; checkpoint inhibitors; biomarkers response; checkpoint ... See more keywords
Abstract A046: Pre-clinical assessment of neratinib sensitivity and biomarkers of response
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a046
Abstract: Introduction: Neratinib is an irreversible pan-HER inhibitor that has shown clinical activity against HER2-amplified (HER2+) and HER2-mutated cancers. Alteration in HER2 is currently the only biomarker of sensitivity to neratinib. To examine other potential biomarkers… read more here.
Keywords: neratinib sensitivity; biomarkers response; cancer; sensitivity ... See more keywords
Characterization of potential predictive biomarkers of response to nivolumab in CheckMate 141 in patients with squamous cell carcinoma of the head and neck (SCCHN).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.5
Abstract: 6050Background: Nivolumab, an anti-programmed death-1 (PD-1) monoclonal antibody, demonstrated longer median overall survival (7.5 vs 5.1 months) and improved response (13.3% vs 5.8%) versus invest... read more here.
Keywords: potential predictive; response; biomarkers response; response nivolumab ... See more keywords
Frequency of genomic biomarkers of response to immunotherapy in sarcoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.11579
Abstract: 11579Background: Recent data (D’Angelo et al, 2018) has suggested possible benefit for a subset of sarcoma patients from immune checkpoint inhibitors (ICPI). We assessed a large sarcoma population ... read more here.
Keywords: sarcoma; frequency genomic; biomarkers response; genomic biomarkers ... See more keywords
Evaluation of biomarkers of response in patients with breast cancer with BRCA 1/2 pathogenic variants treated with PARP inhibitors.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e15188
Abstract: e15188 Background: Several prospective studies highlight the pivotal role of PARP inhibitors (PARPi) in treating BRCA-associated breast cancers (BC), demonstrating a significant overall response rate (ORR) of up to 60% in advanced BC patients with… read more here.
Keywords: oncology; biomarkers response; brca; response ... See more keywords
Biomarkers of response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) with homologous recombination deficiency (HRD).
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.4176
Abstract: 4176 Background: PDAC is associated with a paucity of immune effector cells, low antigenicity, and immunosuppressive factors in the tumor microenvironment (TME); consequently, treatment of unselected PDAC patients with immune checkpoint inhibitors (ICIs) has been… read more here.
Keywords: cohort; biomarkers response; hrd pdac; hrd ... See more keywords
Circulating biomarkers for response prediction of rectal cancer to neoadjuvant chemoradiotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190507084839
Abstract: Rectal cancer response to neoadjuvant chemoradiotherapy (pCRT) is highly variable. In fact, it has been estimated that only about 21 % of patients show pathologic complete response (pCR) after therapy, while in the most of… read more here.
Keywords: neoadjuvant chemoradiotherapy; rectal cancer; response; biomarkers response ... See more keywords
Review of biomarkers for response to immunotherapy in HNSCC microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1037884
Abstract: Head and neck squamous cell carcinoma are one of the most common types of cancer worldwide. Although a variety of treatment methods such as surgery, radiotherapy, chemotherapy, and targeted therapy are widely used in diagnosing… read more here.
Keywords: biomarkers response; immunotherapy; response immunotherapy; review biomarkers ... See more keywords
Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040614
Abstract: Simple Summary Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor. Despite multimodal treatment, the prognosis of GBM patients remains very poor. Oncolytic virotherapy is being evaluated as novel treatment for this patient… read more here.
Keywords: glioblastoma; biomarkers response; response; personalizing oncolytic ... See more keywords