LncRNAs as putative biomarkers and therapeutic targets for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Neurological Sciences"
DOI: 10.1007/s10072-021-05408-7
Abstract: Parkinson’s disease (PD) is known as one of the most common degenerative disorders related to the damage of the central nervous system (CNS). This brain disorder is also characterized by the formation of Lewy bodies… read more here.
Keywords: therapeutic targets; disease; putative biomarkers; parkinson disease ... See more keywords
From biomarkers to therapeutic targets—the promises and perils of long non-coding RNAs in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9718-5
Abstract: Biomarker-driven personalized cancer therapy is a field of growing interest, and several molecular tests have been developed to detect biomarkers that predict, e.g., response of cancers to particular therapies. Identification of these molecules and understanding… read more here.
Keywords: coding rnas; therapeutic targets; long non; non coding ... See more keywords
Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-021-01559-8
Abstract: It has been suggested that dysregulation of long non-coding RNAs (lncRNAs) could be associated with the incidence and development of metabolic disorders. Accordingly, this narrative review described the molecular mechanisms of lncRNAs in the development… read more here.
Keywords: coding rnas; therapeutic targets; long non; non coding ... See more keywords
Long non‐coding RNAs as biomarkers and therapeutic targets: Recent insights into hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.10.007
Abstract: ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer worldwide, and the survival rates of patients with HCC remains quite low after 5 years. Long non‐coding RNAs (LncRNAs) are a novel class of… read more here.
Keywords: hepatocellular carcinoma; coding rnas; therapeutic targets; long non ... See more keywords
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.02.010
Abstract: The diabetic heart is characterized by metabolic disturbances that are often accompanied by local inflammation, oxidative stress, myocardial fibrosis, and cardiomyocyte apoptosis. Overall changes result in contractile dysfunction, concentric left ventricular (LV) hypertrophy, and dilated… read more here.
Keywords: emerging actors; heartbreaker biomarkers; actors diabetic; cardiomyopathy heartbreaker ... See more keywords
Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.1101
Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression through recognition of cognate sequences and interference of transcriptional, translational, or epigenetic processes. Hundreds of miRNA genes have been found in diverse viruses, and many… read more here.
Keywords: micrornas biomarkers; potential micrornas; respiratory viruses; targets respiratory ... See more keywords
Plasma exosomal RNAs has potential as both clinical biomarkers and therapeutic targets of dermatomyositis.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab753
Abstract: OBJECTIVES Dermatomyositis (DM) is characterized by skeletal muscle weakness and cutaneous manifestations. Plasma exosomes (EXOs) contain proteins, RNAs, DNA, and lipid cargoes and are transferred among cells. Deeply investigated plasma EXO RNAs potentially improve our… read more here.
Keywords: hsa mir; plasma exos; therapeutic targets; biomarkers therapeutic ... See more keywords
Non‐coding RNAs in aortic dissection: From biomarkers to therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15802
Abstract: Aortic dissection (AD) is the rupture of the aortic intima, causing the blood in the cavity to enter the middle of the arterial wall. Without urgent and proper treatment, the mortality rate increases to 50%… read more here.
Keywords: coding rnas; therapeutic targets; aortic dissection; non coding ... See more keywords
Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5634724
Abstract: The mitochondrion is a very versatile organelle that participates in some important cancer-associated biological processes, including energy metabolism, oxidative stress, mitochondrial DNA (mtDNA) mutation, cell apoptosis, mitochondria-nuclear communication, dynamics, autophagy, calcium overload, immunity, and drug… read more here.
Keywords: biomarkers therapeutic; ovarian cancer; mitochondrial dysfunction; cancer ... See more keywords
MicroRNA Profiling in Asthma: Potential Biomarkers and Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2016-0231tr
Abstract: &NA; Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. MicroRNAs (miRNAs) are a group of minute, endogenous 22–25 nt RNA elements that join to particular mRNAs… read more here.
Keywords: therapeutic targets; potential biomarkers; profiling asthma; microrna profiling ... See more keywords
The role of ncRNAs in neuroblastoma: mechanisms, biomarkers and therapeutic targets
Sign Up to like & getrecommendations! Published in 2022 at "Biomarker Research"
DOI: 10.1186/s40364-022-00368-2
Abstract: Neuroblastoma (NB) is a malignant tumor in young children that originates from the neural crest of the sympathetic nervous system. Generally, NB occurs in the adrenal glands, but it can also affect the nerve tissues… read more here.
Keywords: therapeutic targets; neuroblastoma mechanisms; mechanisms biomarkers; role ncrnas ... See more keywords