Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug‐membrane interaction for Glioblastoma Multiforme therapy
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DOI: 10.1016/j.ejpb.2019.01.015
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Temozolomide (TMZ) is the first‐line treatment for Glioblastoma Multiforme (GBM). After administration, TMZ is rapidly converted into its active metabolite (MTIC). However, its pharmacological activity is reduced due… read more here.
Keywords: active metabolite; biomembrane models; glioblastoma multiforme; drug ... See more keywords
A Thermodynamic Study on the Interaction between RH-23 Peptide and DMPC-Based Biomembrane Models
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DOI: 10.3390/membranes12121282
Abstract: Investigation of the interaction between drugs and biomembrane models, as a strategy to study and eventually improve drug/substrate interactions, is a crucial factor in preliminary screening. Synthesized peptides represent a source of potential anticancer and… read more here.
Keywords: interaction; dmpc; biomembrane models; study interaction ... See more keywords