Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202315166
Abstract: Developing new drugs is a complex, time‐consuming, and expensive process, essential to identify potential pharmacokinetic issues in the early stages to avoid investment in nonpromising candidates. Nearly half of all drug targets and key drug‐metabolizing… read more here.
Keywords: review; lipid microfluidic; screening applications; microfluidic biomimetic ... See more keywords
Biomimetic models of the glomerulus
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-021-00528-x
Abstract: The use of biomimetic models of the glomerulus has the potential to improve our understanding of the pathogenesis of kidney diseases and to enable progress in therapeutics. Current in vitro models comprise organ-on-a-chip, scaffold-based and… read more here.
Keywords: complexity; models glomerulus; chip; biofabrication ... See more keywords
Biomimetic models of the human eye, and their applications
Sign Up to like & getrecommendations! Published in 2021 at "Nanotechnology"
DOI: 10.1088/1361-6528/abf3ee
Abstract: Replicating the functionality of the human eye has been a challenge for more than a century, creating a great wealth of biomimetic and bioinspired devices, and providing ever improving models of the eye for myriad… read more here.
Keywords: human eye; biomimetic models; components eye; models human ... See more keywords
Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis
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DOI: 10.3390/bioengineering7030113
Abstract: Atherosclerosis, the inflammation of artery walls due to the accumulation of lipids, is the most common underlying cause for cardiovascular diseases. Monocytes and macrophages are major cells that contribute to the initiation and progression of… read more here.
Keywords: monocytes macrophages; biomimetic models; models investigating; density ... See more keywords
Encapsulation of Vitamin C by Glycerol-Derived Dendrimers, Their Interaction with Biomimetic Models of Stratum corneum and Their Cytotoxicity
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DOI: 10.3390/molecules27228022
Abstract: Vitamin C is one of the most sensitive cosmetic active ingredients. To avoid its degradation, its encapsulation into biobased carriers such as dendrimers is one alternative of interest. In this work, we wanted to evaluate… read more here.
Keywords: cytotoxicity; stratum corneum; models stratum; pamam ... See more keywords
Lipid Biomimetic Models as Simple Yet Complex Tools to Predict Skin Permeation and Drug–Membrane Biophysical Interactions
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics16060807
Abstract: The barrier function of the skin is primarily determined by its outermost layer, the Stratum Corneum (SC). The SC consists of corneocytes embedded in a lipid matrix composed mainly of ceramides, cholesterol, and free fatty… read more here.
Keywords: simple yet; models simple; permeation; lipid matrix ... See more keywords