Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine‐Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204961
Abstract: T cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It is crucial to innovatively reverse the T cell dysfunction for improving GBM immunotherapy. Herein, T… read more here.
Keywords: cell; cell dysfunction; biomimetic nanoparticles; immunotherapy ... See more keywords
Biomimetic Lipid Polymer Nanoparticles for Drug Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0319-2_4
Abstract: Biomimetic nanoparticles are hybrid nanostructures in which the uppermost layer is similar to a cell membrane. In these nanoparticles, lipids and biopolymers can be organized to improve drug incorporation and delivery. This report provides instructions… read more here.
Keywords: delivery; lipid polymer; drug; biomimetic lipid ... See more keywords
Organotropic Targeting of Biomimetic Nanoparticles to Treat Lung Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00599
Abstract: Active targeting strategies aimed at improving drug homing while reducing systemic toxicity are widely being pursued in the growing field of nanomedicine. While they can be effective, these approaches often require the identification of cell-specific… read more here.
Keywords: organotropic targeting; targeting biomimetic; biomimetic nanoparticles; disease ... See more keywords
Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "ACS Nano"
DOI: 10.1021/acsnano.0c05792
Abstract: Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes. Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However,… read more here.
Keywords: leukocyte based; based biomimetic; inflammation targeting; enhancing inflammation ... See more keywords
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
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DOI: 10.1038/s41467-019-11718-4
Abstract: Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy.… read more here.
Keywords: drug; dox psinps; cancer chemotherapy; cancer ... See more keywords
Macrophage Membrane-Derived Biomimetic Nanoparticles for Treatment of Cytokine Release Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3324
Abstract: Cytokine release syndrome (CRS) is a severe complication of infectious diseases like Coronavirus disease 2019 (COVID-19) that cause serious damage to public health. Currently, supportive therapy is still the main therapeutic strategy exists for CRS… read more here.
Keywords: macrophage membrane; biomimetic nanoparticles; derived biomimetic; membrane derived ... See more keywords
Research Progress of Cell Membrane Biomimetic Nanoparticles for Tumor Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-022-03673-9
Abstract: Nanoparticles have unique properties and high design flexibility, which are thought to be safe, site-specific, and efficient drug delivery systems. However, nanoparticles as exogenous materials can provide recognition and be eliminated by the body’s immune… read more here.
Keywords: biomimetic nanoparticles; delivery; membrane; cell membrane ... See more keywords
Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00627
Abstract: Nanoparticle-based drug delivery systems have been synthesized from a wide array of materials. The therapeutic success of these platforms hinges upon their ability to favorably interact with the biological environment (both systemically and locally) and… read more here.
Keywords: membrane based; system; cell membrane; based biomimetic ... See more keywords
Membrane-camouflaged biomimetic nanoparticles as potential immunomodulatory solutions for sepsis: An overview
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1111963
Abstract: Sepsis is a life-threatening organ dysfunction due to dysregulated host responses induced by infection. The presence of immune disturbance is key to the onset and development of sepsis but has remarkably limited therapeutic options. Advances… read more here.
Keywords: sepsis; nanoparticles potential; biomimetic nanoparticles; camouflaged biomimetic ... See more keywords
Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1111855
Abstract: Introduction Osteosarcoma tumors are the most common malignant bone tumors in children and adolescents. Their treatment usually requires surgical removal of all detectable cancerous tissue and multidrug chemotherapy; however, the prognosis for patients with unresectable… read more here.
Keywords: osteosarcoma; biomimetic nanoparticles; tumor; doxorubicin ... See more keywords
Cell Membrane Biomimetic Nanoparticles with Potential in Treatment of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052336
Abstract: Alzheimer’s disease (AD) is to blame for about 60% of dementia cases worldwide. The blood–brain barrier (BBB) prevents many medications for AD from having clinical therapeutic effects that can be used to treat the affected… read more here.
Keywords: membrane biomimetic; alzheimer disease; cell membrane; biomimetic nanoparticles ... See more keywords