Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine‐Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204961
Abstract: T cell dysfunction‐induced tumor immune escape is particularly severe in glioblastoma (GBM), and significantly affects the efficacy of immunotherapy. It is crucial to innovatively reverse the T cell dysfunction for improving GBM immunotherapy. Herein, T… read more here.
Keywords: cell; cell dysfunction; biomimetic nanoparticles; immunotherapy ... See more keywords
Biomimetic Lipid Polymer Nanoparticles for Drug Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0319-2_4
Abstract: Biomimetic nanoparticles are hybrid nanostructures in which the uppermost layer is similar to a cell membrane. In these nanoparticles, lipids and biopolymers can be organized to improve drug incorporation and delivery. This report provides instructions… read more here.
Keywords: delivery; lipid polymer; drug; biomimetic lipid ... See more keywords
Organotropic Targeting of Biomimetic Nanoparticles to Treat Lung Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00599
Abstract: Active targeting strategies aimed at improving drug homing while reducing systemic toxicity are widely being pursued in the growing field of nanomedicine. While they can be effective, these approaches often require the identification of cell-specific… read more here.
Keywords: organotropic targeting; targeting biomimetic; biomimetic nanoparticles; disease ... See more keywords
Geniposide-Loaded Biomimetic Nanoparticles Modulate HMOX1 To Alleviate Neuroinflammation in Depression.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00230
Abstract: Depression is a debilitating mental disorder closely linked to neuroinflammation and dysregulated microglial activity. This study investigates a novel nanotherapeutic strategy utilizing geniposide (GEN)-loaded biomimetic nanoparticles (CSPG@CM) to target microglia and modulate heme oxygenase-1 (HMOX1),… read more here.
Keywords: loaded biomimetic; neuroinflammation; nanoparticles modulate; depression ... See more keywords
Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "ACS Nano"
DOI: 10.1021/acsnano.0c05792
Abstract: Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes. Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However,… read more here.
Keywords: leukocyte based; based biomimetic; inflammation targeting; enhancing inflammation ... See more keywords
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11718-4
Abstract: Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy.… read more here.
Keywords: drug; dox psinps; cancer chemotherapy; cancer ... See more keywords
Retrospective perspectives and future trends in nanomedicine treatment: from single membranes to hybrid membranes.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d4nr04999c
Abstract: At present, various diseases seriously threaten human life and health, and the development of nanodrug delivery systems has brought about a turnaround for traditional drug treatments, with nanoparticles being precisely targeted to improve bioavailability. Surface… read more here.
Keywords: treatment; cell membrane; treatment various; various diseases ... See more keywords
miRNA-loaded biomimetic nanoparticles orchestrate gut microbe to ameliorate inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adw5984
Abstract: Modulation of gut microbiota has emerged as a promising therapeutic strategy for inflammatory bowel disease (IBD). However, current interventions such as probiotics and fecal microbiota transplantation remain limited by insufficient safety and efficacy. To address… read more here.
Keywords: loaded biomimetic; inflammatory bowel; bowel disease; mirna loaded ... See more keywords
Macrophage Membrane-Derived Biomimetic Nanoparticles for Treatment of Cytokine Release Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3324
Abstract: Cytokine release syndrome (CRS) is a severe complication of infectious diseases like Coronavirus disease 2019 (COVID-19) that cause serious damage to public health. Currently, supportive therapy is still the main therapeutic strategy exists for CRS… read more here.
Keywords: macrophage membrane; biomimetic nanoparticles; derived biomimetic; membrane derived ... See more keywords
Research Progress of Cell Membrane Biomimetic Nanoparticles for Tumor Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-022-03673-9
Abstract: Nanoparticles have unique properties and high design flexibility, which are thought to be safe, site-specific, and efficient drug delivery systems. However, nanoparticles as exogenous materials can provide recognition and be eliminated by the body’s immune… read more here.
Keywords: biomimetic nanoparticles; delivery; membrane; cell membrane ... See more keywords
Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03260-x
Abstract: This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to… read more here.
Keywords: neutrophil extracellular; nanoparticles target; loaded biomimetic; astragaloside loaded ... See more keywords