Biomimetic Total Syntheses of Ergot Alkaloids via Decarboxylative Giese Coupling.
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DOI: 10.1021/acs.orglett.0c03867
Abstract: Biomimetic total syntheses of Festuclavine and Pyroclavine were achieved by a sequential radical coupling. The key steps include intramolecular decarboxylative Giese reaction to form the central C ring and 4-nitrobenzenesulfonyl (Ns)-directed indole C4-H olefination to… read more here.
Keywords: total syntheses; biomimetic total; alkaloids via; decarboxylative giese ... See more keywords
Biomimetic Total Syntheses of Callistrilones A, B, and D.
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DOI: 10.1021/acs.orglett.7b03815
Abstract: A biomimetic total syntheses of antibacterial natural products (±)-callistrilones A, B, and D, the first triketone-phloroglucinol-monoterpene hybrids with an unprecedented [1]benzofuro[2,3-a]xanthene and [1]benzofuro[3,2-b]xanthene pentacyclic ring system along with the postulated biosynthetic intermediate, isolated from the… read more here.
Keywords: total syntheses; biomimetic total; syntheses callistrilones;
Biomimetic Total Synthesis and Paired Omics Identify an Intermolecular Diels–Alder Reaction as the Key Step in Lugdunomycin Biosynthesis
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DOI: 10.1021/jacs.5c01883
Abstract: Microbial natural products are the basis of the majority of clinical drugs, where the discovery of truly novel structural scaffolds to fill the discovery pipelines is a prerequisite. Lugdunomycin is a highly rearranged angucycline polyketide… read more here.
Keywords: biomimetic total; biosynthesis; intermolecular diels; alder reaction ... See more keywords
Racemic trinorsesquiterpenoids from the Beihai sponge Spongia officinalis: structure and biomimetic total synthesis
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DOI: 10.1039/c7qo01091e
Abstract: Two rare new furan butanolides, namely sponalisolides A (1) and B (2), characterized by an unprecedented furan-bearing trinorsesquiterpene alkyl chain connecting either a butanolide (1) or an N-acyl homoserine lactone moiety (2), were isolated in… read more here.
Keywords: sponge spongia; spongia officinalis; total synthesis; biomimetic total ... See more keywords
Biomimetic total synthesis of homodimericin A
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DOI: 10.1039/c7qo01161j
Abstract: Homodimericin A is a fascinating fungal metabolite and a highly oxygenated cage-like polyketide. A practical total synthesis of homodimericin A has been achieved in 7 steps. The synthesis features a basic aqueous buffer promoted dimerization… read more here.
Keywords: synthesis homodimericin; chemistry; homodimericin; total synthesis ... See more keywords