Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202104704
Abstract: Biomolecular condensates have been demonstrated as a ubiquitous phenomenon in biological systems and play a crucial role in controlling cellular functions. However, the spatiotemporal construction of artificial biomolecular condensates with functions remains challenging and has… read more here.
Keywords: biomolecular condensates; drug resistance; multiple drug; resistance ... See more keywords
Spatial genome organization, TGFβ, and biomolecular condensates: Do they talk during development?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200145
Abstract: Cis‐regulatory elements govern gene expression programs to determine cell identity during development. Recently, the possibility that multiple enhancers are orchestrated in clusters of enhancers has been suggested. How these elements are arranged in the 3D… read more here.
Keywords: development; spatial genome; tgf biomolecular; organization tgf ... See more keywords
Metastable biomolecular condensates of interferon-inducible antiviral Mx-family GTPases: A paradigm shift in the last three years
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biosciences"
DOI: 10.1007/s12038-021-00187-x
Abstract: Membraneless organelles (MLOs) in the cytoplasm and nucleus in the form of phase-separated biomolecular condensates are increasingly viewed as critical in regulating diverse cellular functions. We summarize a paradigm shift over the last 3 years… read more here.
Keywords: biomolecular condensates; paradigm shift; shift last; phase separated ... See more keywords
Intrinsically disordered proteins and biomolecular condensates as drug targets.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.02.009
Abstract: Intrinsically disordered domains represent attractive therapeutic targets because they play key roles in cancer, as well as in neurodegenerative and infectious diseases. They are, however, considered undruggable because they do not form stable binding pockets… read more here.
Keywords: biomolecular condensates; condensates drug; proteins biomolecular; disordered proteins ... See more keywords
Noise buffering by biomolecular condensates in glucose sensing.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.12.002
Abstract: Many cellular processes involve buffering mechanisms against noise to enhance state stability. Such processes include the cell cycle and the switch between respiration and fermentation. In recent years, protein aggregation/condensation has emerged as an important… read more here.
Keywords: biomolecular condensates; buffering biomolecular; glucose sensing; biology ... See more keywords
Who's In and Who's Out-Compositional Control of Biomolecular Condensates.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.08.003
Abstract: Biomolecular condensates are two- and three-dimensional compartments in eukaryotic cells that concentrate specific collections of molecules without an encapsulating membrane. Many condensates behave as dynamic liquids and appear to form through liquid-liquid phase separation driven… read more here.
Keywords: biomolecular condensates; control; condensate composition; control biomolecular ... See more keywords
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.01.005
Abstract: Stresses such as heat shock trigger the formation of protein aggregates and the induction of a disaggregation system composed of molecular chaperones. Recent work reveals that several cases of apparent heat-induced aggregation, long thought to… read more here.
Keywords: chaperones directly; heat induced; directly efficiently; heat ... See more keywords
Dynamic Monitoring of Phase-Separated Biomolecular Condensates by Photoluminescence Lifetime Imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c05011
Abstract: The formation of biomolecular condensates is driven by liquid-liquid phase separation, which is prevalent in cells to govern crucial cellular functions. However, understanding the properties of phase-separated condensates remains very challenging for the lack of… read more here.
Keywords: biomolecular condensates; phase; photoluminescence lifetime; phase separated ... See more keywords
Regulation of Biomolecular Condensates by Poly(ADP-ribose).
Sign Up to like & getrecommendations! Published in 2023 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.2c00851
Abstract: Biomolecular condensates are reversible compartments that form through a process called phase separation. Post-translational modifications like ADP-ribosylation can nucleate the formation of these condensates by accelerating the self-association of proteins. Poly(ADP-ribose) (PAR) chains are remarkably… read more here.
Keywords: adp ribosylation; regulation biomolecular; par; biomolecular condensates ... See more keywords
Repurposing Peptide Nanomaterials as Synthetic Biomolecular Condensates in Bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00078
Abstract: Peptide nanomaterials exhibit diverse applications in vitro, such as drug delivery. Here, we consider the utility of de novo peptide nanomaterials to organize biochemistry within the bacterial cytoplasm. Toward this goal, we discovered that ABC… read more here.
Keywords: synthetic biomolecular; repurposing peptide; triblock peptides; peptide nanomaterials ... See more keywords
A framework for understanding the functions of biomolecular condensates across scales
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-020-00303-z
Abstract: Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in the cytoplasm and on membranes. They are also implicated in a wide range of cellular functions, organizing molecules that act in processes ranging… read more here.
Keywords: biomolecular condensates; understanding functions; length scales; biology ... See more keywords