Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200444
Abstract: Herein we illustrate the formation and characterization of new paramagnetic ruthenium compounds, trans‐P‐[RuCl(PPh3)2(pmt)]Cl (1) (Hpmt=1‐((pyridin‐2‐yl)methylene)thiosemicarbazide), trans‐P‐[RuCl(PPh3)2(tmc)]Cl (2) (Htmc=1‐((thiophen‐2‐yl)methylene)thiosemicarbazide) and a diamagnetic ruthenium complex, cis‐Cl, trans‐P‐[RuCl2(PPh3)2(btm)] (3) (btm=2‐((5‐hydroxypentylimino)methyl)benzothiazole). Agarose gel electrophoresis experiments of the metal compounds… read more here.
Keywords: biomolecular interactions; interactions cytotoxic; ruthenium compounds; ruthenium ... See more keywords
Applications of Protein Fragment Complementation Assays for Analyzing Biomolecular Interactions and Biochemical Networks in Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00154
Abstract: Protein-protein interactions (PPIs) are indispensable for the dynamic assembly of multiprotein complexes that are central players of nearly all of the intracellular biological processes, such as signaling pathways, metabolic pathways, formation of intracellular organelles, establishment… read more here.
Keywords: applications protein; fragment complementation; biomolecular interactions; protein fragment ... See more keywords
Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c04961
Abstract: Biomolecular interactions compose a fundamental element of all life forms and are the biological basis of many biomedical assays. However, current methods for detecting biomolecular interactions have limitations in sensitivity and specificity. Here, using nitrogen-vacancy… read more here.
Keywords: magnetic detection; biomolecular interactions; digital magnetic; interactions single ... See more keywords
Thiophene-Extended Fluorescent Nucleosides as Molecular Rotor-Type Fluorogenic Sensors for Biomolecular Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "ACS sensors"
DOI: 10.1021/acssensors.2c02617
Abstract: Fluorescent molecular rotors are versatile tools for the investigation of biomolecular interactions and the monitoring of microenvironmental changes in biological systems. They can transform invisible information into a fluorescence signal as a straightforward response. Their… read more here.
Keywords: biomolecular interactions; thiophene extended; rotor; rotor type ... See more keywords
Thiosemicarbazone(s)-anchored water soluble mono- and bimetallic Cu(ii) complexes: enzyme-like activities, biomolecular interactions, anticancer property and real-time live cytotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt01309a
Abstract: The reactions of CuCl2·2H2O with chromone thiosemicarbazone ligands containing a -H or -CH3 substituent on terminal N yielded monometallic Cu(ii) complexes [Cu(HL1)Cl2] (1) and [Cu(HL2)Cl2] (2), whereas bimetallic Cu(ii) complexes [Cu(μ-Cl)(HL3)]2Cl2 (3), [Cu(μ-Cl)(HL4)]2Cl2 (4) and… read more here.
Keywords: time live; real time; bimetallic complexes; biomolecular interactions ... See more keywords
Potential Inhibitory Biomolecular Interactions of Natural Compounds With Different Molecular Targets of Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics and Biology Insights"
DOI: 10.1177/11779322231167970
Abstract: Type II diabetes is an endemic disease and is responsible for approximately 90% to 95% of diabetes cases. The pathophysiological distortions are majorly β-cell dysfunction, insulin resistance, and long-term inflammation, which all progressively unsettle the… read more here.
Keywords: biomolecular interactions; natural compounds; inhibitory biomolecular; potential inhibitory ... See more keywords
Cysteine-Encapsulated Liposome for Investigating Biomolecular Interactions at Lipid Membranes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810566
Abstract: The development of a strategy to investigate interfacial phenomena at lipid membranes is practically useful because most essential biomolecular interactions occur at cell membranes. In this study, a colorimetric method based on cysteine-encapsulated liposomes was… read more here.
Keywords: lipid membranes; biomolecular interactions; gold nanoparticles; cysteine encapsulated ... See more keywords
Looking at Biomolecular Interactions through the Lens of Correlated Fluorescence Microscopy and Optical Tweezers
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032668
Abstract: Understanding complex biological events at the molecular level paves the path to determine mechanistic processes across the timescale necessary for breakthrough discoveries. While various conventional biophysical methods provide some information for understanding biological systems, they… read more here.
Keywords: single molecule; biomolecular interactions; optical tweezers; microscopy ... See more keywords
Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196430
Abstract: This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively large and flat.… read more here.
Keywords: interactions drug; biomolecular interactions; scaffold targeting; using cyclotide ... See more keywords