Conditions to minimize soft single biomolecule deformation when imaging with atomic force microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2016.12.011
Abstract: A recurrent interrogation when imaging soft biomolecules using atomic force microscopy (AFM) is the putative deformation of molecules leading to a bias in recording true topographical surfaces. Deformation of biomolecules comes from three sources: sample… read more here.
Keywords: microscopy; force microscopy; biomolecule; deformation ... See more keywords
Electromagnetic study of surface enhanced Raman scattering of plasmonic-biomolecule: An interaction between nanodimer and single biomolecule
Sign Up to like & getrecommendations! Published in 2017 at "Solid State Communications"
DOI: 10.1016/j.ssc.2017.03.010
Abstract: Abstract In this article we have investigated the electromagnetic surface enhanced Raman scattering (SERS) of single biomolecule adsorbed at the surface of spherical nanodimer. The SERS mechanism has been studied using first principle approach for… read more here.
Keywords: raman scattering; surface enhanced; enhanced raman; single biomolecule ... See more keywords
Balanced detection method using optical affinity sensors for quick measurement of biomolecule concentrations.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00637
Abstract: To determine the concentration of biomolecules using a label-free optical biosensor, it is necessary to measure the serial signal from the reaction starting point, which is inconvenient for practical applications. Here, we propose an alternative… read more here.
Keywords: detection; balanced detection; detection method; biomolecule ... See more keywords
Electrothermal active control of preconcentrated biomolecule plugs.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b03917
Abstract: Concentration-polarization (CP)-based biomolecule preconcentration is highly effective in enhancing the detectfiion sensitivity, yet fails to precisely and dynamically control the location of the preconcentrated biomolecule plug to ensure overlap with the sensing region (e.g. immobilized… read more here.
Keywords: location preconcentrated; electrothermal active; preconcentrated biomolecule; biomolecule ... See more keywords
Electrokinetic Active Particles for Motion-Based Biomolecule Detection.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.3c00319
Abstract: Detection of biomolecules is essential for patient diagnosis, disease management, and numerous other applications. Recently, nano- and microparticle-based detection has been explored for improving traditional assays by reducing required sample volumes and assay times as… read more here.
Keywords: active particles; biomolecule; biomolecule detection; detection ... See more keywords
A Simplistic Single-Step Method for Preparing Biomimetic Nanoparticles from Endogenous Biomaterials.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c17302
Abstract: Many works utilize products isolated from nature as capping agents to functionalize gold nanoparticles for targeting and therapeutic applications. Some of the most advanced of these strategies utilize complex multicomponent biomaterials, such as whole cell-membranes,… read more here.
Keywords: microscopy; step; biomolecule; single step ... See more keywords
Structural Analysis of Biomolecules through a Combination of Mobility Capillary Electrophoresis and Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03224
Abstract: The 3D structures of biomolecules determine their biological function. Established methods in biomolecule structure determination typically require purification, crystallization, or modification of target molecules, which limits their applications for analyzing trace amounts of biomolecules in… read more here.
Keywords: capillary electrophoresis; analysis; biomolecule; analysis biomolecules ... See more keywords
Systematic molecular evolution enables robust biomolecule discovery
Sign Up to like & getrecommendations! Published in 2021 at "Nature Methods"
DOI: 10.1038/s41592-021-01348-4
Abstract: Evolution occurs when selective pressures from the environment shape inherited variation over time. Within the laboratory, evolution is commonly used to engineer proteins and RNA, but experimental constraints have limited the ability to reproducibly and… read more here.
Keywords: robotics; continuous evolution; biomolecule; phage ... See more keywords
Enantioselective recognition of an isomeric ligand by a biomolecule: mechanistic insights into static and dynamic enantiomeric behavior and structural flexibility.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00378a
Abstract: Chirality is a ubiquitous basic attribute of nature, which inseparably relates to the life activity of living organisms. However, enantiomeric differences have still failed to arouse enough attention during the biological evaluation and practical application… read more here.
Keywords: biomolecule; flexibility; structural flexibility; biorecognition ... See more keywords
The biomolecule corona of lipid nanoparticles contains circulating cell-free DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale horizons"
DOI: 10.1039/d0nh00333f
Abstract: The spontaneous adsorption of biomolecules onto the surface of nanoparticles (NPs) in complex physiological biofluids has been widely investigated over the last decade. Characterisation of the protein composition of the 'biomolecule corona' has dominated research… read more here.
Keywords: biomolecule; biomolecule corona; free dna; cell free ... See more keywords
Experimental study on single biomolecule sensing using MoS2-graphene heterostructure nanopores.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr04485d
Abstract: Solid-state nanopores play an important role in sensing single-biomolecules such as DNA and proteins. However, an ultra-short translocation time hinders nanopores from acquiring more detailed information about biomolecules, and further applications such as sequencing and… read more here.
Keywords: mos2 graphene; biomolecule; translocation; bsa ... See more keywords