Bioorthogonal chemistry: Optimization and application updates during 2013–2017
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.04.058
Abstract: Abstract Bioorthogonal chemical groups to tag naturally occurring biomolecules in their native setting is a powerful tool for studying and manipulating biological processes, whereby unique functional groups incorporated into target biomolecules can be detected in… read more here.
Keywords: optimization application; application updates; chemistry; bioorthogonal chemistry ... See more keywords
Copper-Containing Artificial Polyenzymes as a Clickase for Bioorthogonal Chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00363
Abstract: Artificial polyenzymes (ArPoly) are tailored combinations of universal protein scaffolds and polymers newly proposed as promising alternatives to natural enzymes to expand the biocatalyst toolbox. The concept of ArPoly has been continuously extended to metal-containing… read more here.
Keywords: copper; chemistry; chemistry copper; copper containing ... See more keywords
A Motor-Based Carbonaceous Nanocalabash Catalyst for Deep-Layered Bioorthogonal Chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09599
Abstract: Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has been widely regarded as a promising avenue in bioorthogonal chemistry. The emerging heterogeneous copper catalysts have been developed with a series of exciting applications such as in situ activation… read more here.
Keywords: catalyst; chemistry; carbonaceous nanocalabash; deep layered ... See more keywords
Optimized aqueous Kinugasa reactions for bioorthogonal chemistry applications.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09473c
Abstract: Kinugasa reactions hold potential for bioorthogonal chemistry in that the reagents can be biocompatible. Unlike other bioorthogonal reaction products, β-lactams are potentially reactive, which can be useful for synthesizing new biomaterials. A limiting factor for… read more here.
Keywords: chemistry; kinugasa reactions; bioorthogonal chemistry; reaction ... See more keywords
Metabolic glycoengineering - exploring glycosylation with bioorthogonal chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d2cs00764a
Abstract: Glycans are involved in numerous biological recognition events. Being secondary gene products, their labeling by genetic methods - comparable to GFP labeling of proteins - is not possible. To overcome this limitation, metabolic glycoengineering (MGE,… read more here.
Keywords: glycosylation bioorthogonal; exploring glycosylation; chemistry; metabolic glycoengineering ... See more keywords
Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr06056f
Abstract: Bioorthogonal chemistry enables researchers to manipulate bioactive molecules in living systems. These highly selective and biocompatible reactions can be carried out in various complex environments. Over the past two decades, a considerable number of strides… read more here.
Keywords: nanotechnology; chemistry; chemistry makes; bioorthogonal chemistry ... See more keywords
Tetrazine bioorthogonal chemistry derived in vivo imaging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1055823
Abstract: Bioorthogonal chemistry represents plenty of highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations without unexpected side reactions towards miscellaneous endogenous functional groups. Arise from the strict demands of physiological reactions,… read more here.
Keywords: bioorthogonal chemistry; derived vivo; chemistry; vivo imaging ... See more keywords
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122569
Abstract: Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity has… read more here.
Keywords: expressing cancers; grpr expressing; chemistry; bioorthogonal chemistry ... See more keywords