"One-stitch" bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120823
Abstract: Bioorthogonal prodrug activation is fascinating but suffers from staggered administration of prodrug and trigger, which would not only reduce the therapeutic effect but bring great inconvenience for clinical application. Herein, we report a new cross-linked… read more here.
Keywords: bioorthogonal prodrug; prodrug activation; prodrug; one stitch ... See more keywords
On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01493
Abstract: Although a myriad of bioorthogonal prodrugs have been developed, very few of them present both fast reaction kinetics and complete cleavage. Herein, we report a new bioorthogonal prodrug strategy with both fast reaction kinetics (k2:… read more here.
Keywords: reaction; reaction kinetics; bioorthogonal prodrug; demand activation ... See more keywords
Intracellular fluorogenic supramolecular assemblies for self-reporting bioorthogonal prodrug activation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00972b
Abstract: A visual drug delivery system (DDS) is urgently needed for precision medicine. DDS-mediated bioorthogonal prodrug activation strategies have demonstrated remarkable advantages in enlarging a therapeutic index via the alleviation of adverse drug reactions. However, the… read more here.
Keywords: supramolecular assemblies; self reporting; prodrug activation; bioorthogonal prodrug ... See more keywords