A Therapeutic Pretargeting Strategy for Triple‐Negative Breast Cancer Based on a Bioorthogonal Reaction and a Self‐Assembled Peptide
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202313090
Abstract: Triple‐negative breast cancer (TNBC), a disease with a poor prognosis and high mortality, is difficult to targeted therapy, due to the metastatic nature of TNBC cells and their lack of estrogen, progesterone, and Her‐2/Neu receptor… read more here.
Keywords: self assembled; pretargeting strategy; assembled peptide; bioorthogonal reaction ... See more keywords
Bridgehead Alkene-Enabled Strain-Driven Bioorthogonal Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01895
Abstract: Herein, we report a novel bioorthogonal reaction that hinges on a bridgehead alkene (BHA)-enabled inverse-electron-demand Diels-Alder (IEDDA) cycloaddition. Readily accessible from natural product β-caryophyllene, the strained BHA displays high reactivity toward the IEDDA reaction while… read more here.
Keywords: alkene enabled; bioorthogonal reaction; reaction; strain driven ... See more keywords
Bioorthogonal Reaction of β-Chloroacroleins with meta-Aminothiophenol to Develop Near-Infrared Fluorogenic Probes for Simultaneous Two-color Imaging.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c16074
Abstract: Highly fluorogenic probe based bioorthogonal chemistry has become a promising tool in biomedical applications. However, the majority of fluorogenic probes are designed by introducing a bioorthogonal partner as a fluorescence quencher into classical fluorophores, and… read more here.
Keywords: fluorogenic probes; meta aminothiophenol; bioorthogonal reaction; two color ... See more keywords