Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry Letters"
DOI: 10.2210/pdb6cge/pdb
Abstract: 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) plays a pivotal role in the progression of estrogen-related diseases because of its involvement in the biosynthesis of estradiol (E2), constituting a valuable therapeutic target for endocrine treatment. In the… read more here.
Keywords: biophysical chemistry; inhibitor; chemistry; low reactivity ... See more keywords