Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191162
Abstract: Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-protein interactions… read more here.
Keywords: protein; chain; antibody; disrupted schizophrenia ... See more keywords
Biophysical insights into the molecular mechanisms of beta amyloid aggregation and its toxic effects in Alzheimer’s disease
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DOI: 10.3389/fmolb.2025.1704653
Abstract: Alzheimer’s disease is recognized as the most common neurodegenerative disorder, characterized by the presence of amyloid plaques, which have consistently garnered significant attention. Since the disease was first identified, extensive research has been devoted to… read more here.
Keywords: biophysical insights; alzheimer disease; disease; insights molecular ... See more keywords
Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073468
Abstract: (1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated with acute recurrent pancreatitis (ARP) and chronic pancreatitis… read more here.
Keywords: spink1; biophysical insights; cationic trypsin; human cationic ... See more keywords