Biophysical and modeling-based approach for the identification of inhibitors against DOHH from Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elac014
Abstract: The amino acid hypusine (Nε-4-amino-2-hydroxybutyl(lysine)) occurs only in isoforms of eukaryotic translation factor 5A (eIF5A) and has a role in initiating protein translation. Hypusinated eIF5A promotes translation and modulates mitochondrial function and oxygen consumption rates.… read more here.
Keywords: based approach; modeling based; biophysical modeling; leishmania donovani ... See more keywords
Person-Specific Biophysical Modeling of Alpha-Motoneuron Pools Driven by in vivo Decoded Neural Synaptic Input
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2023.3247873
Abstract: Interfacing with alpha-motoneurons (MNs) is key to understand and control motor impairment and neurorehabilitation technologies. Depending on the neurophysiological condition of each individual, MN pools exhibit distinct neuro-anatomical properties and firing behaviors. Hence, the ability… read more here.
Keywords: person specific; specific biophysical; alpha motoneuron; person ... See more keywords
Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
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DOI: 10.1177/15593258221138506
Abstract: This review article describes our simplified biophysical model for the response of a group of cells to ionizing radiation. The model, which is a product of 10 years of studies, acts as (a) a comprehensive… read more here.
Keywords: monte carlo; ionizing radiation; modeling ionizing; radiation influence ... See more keywords
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14102089
Abstract: The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen. SARS-CoV-2 has four structural proteins: Envelope (E), Membrane (M),… read more here.
Keywords: condensation; modeling sars; biophysical modeling; structural proteins ... See more keywords