Can biophysical models of dendritic spines be used to explore synaptic changes associated with addiction?
Sign Up to like & getrecommendations! Published in 2022 at "Physical Biology"
DOI: 10.1088/1478-3975/ac6cbe
Abstract: Effective treatments that prevent or reduce drug relapse vulnerability should be developed to relieve the high burden of drug addiction on society. This will only be possible by enhancing the understanding of the molecular mechanisms… read more here.
Keywords: synaptic changes; dendritic spines; addiction; drug ... See more keywords
Biophysical models of dispersal contribute to seascape genetic analyses
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0024
Abstract: Dispersal is generally difficult to directly observe. Instead, dispersal is often inferred from genetic markers and biophysical modelling where a correspondence indicates that dispersal routes and barriers explain a significant part of population genetic differentiation.… read more here.
Keywords: models dispersal; seascape genetic; genetic differentiation; biophysical models ... See more keywords
Biophysical approaches to predicting species vulnerability
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DOI: 10.1111/gcb.16565
Abstract: Earth's climate is warming rapidly at rates which, by some estimates, exceed those of climatic niche evolution among vertebrate animals by >10,000fold (Quintero & Wiens, 2013). Assessing this ubiquitous threat to biodiversity requires a variety… read more here.
Keywords: biophysical modelling; climate; functional traits; water ... See more keywords
An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.675867
Abstract: The formulation of in silico biophysical models generally requires optimization strategies for reproducing experimentally observed phenomena. In electrophysiological modeling, robust nonlinear regressive methods are often crucial for guaranteeing high fidelity models. Human induced pluripotent stem… read more here.
Keywords: biophysical models; genetic algorithm; pharmacology; model ... See more keywords