Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC.
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DOI: 10.1007/978-1-0716-1476-1_3
Abstract: The C-terminal region of the c-MYC transcription factor consists of approximately 100 amino acids that in its native state does not adopt a stable structure. When this region binds to the obligatory partner MAX via… read more here.
Keywords: methods study; biophysical structural; structural methods; human myc ... See more keywords
Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ.
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DOI: 10.1016/j.jmb.2021.166838
Abstract: Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation,… read more here.
Keywords: pi3k; ras binding; binding domains; pi3k pi3k ... See more keywords