Microbioreactors for nutrient-controlled microbial cultures: Bridging the gap between bioprocess development and industrial use.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200549
Abstract: It is common practice in the development of bioprocesses to genetically modify a microorganism and study a large number of resulting mutants in order to select the ones that perform best for use at the… read more here.
Keywords: nutrient controlled; bioprocess development; development; development industrial ... See more keywords
Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2377
Abstract: Microbial bioprocesses need to be designed to be transferable from lab scale to production scale as well as between setups. Although substantial effort is invested to control technological parameters, usually the only true constant parameter… read more here.
Keywords: workflow transferable; development workflow; transferable physiological; physiology ... See more keywords
Enzymes in biotechnology: Critical platform technologies for bioprocess development.
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DOI: 10.1016/j.copbio.2020.12.003
Abstract: Enzymes are core elements of biosynthetic pathways employed in the synthesis of numerous bioproducts. Here, we review enzyme promiscuity, enzyme engineering, enzyme immobilization, and cell-free systems as fundamental strategies of bioprocess development. Initially, promiscuous enzymes… read more here.
Keywords: biotechnology critical; platform technologies; critical platform; bioprocess development ... See more keywords
Pluripotent stem cells for drug development and therapy: bioprocess development challenges
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DOI: 10.1080/07853890.2018.1560031
Abstract: Human pluripotent Stem Cells (hPSC) have an enormous potential as a source for cell replacement therapies, tissue engineering, and in vitro toxicology applications. The lack of standardized and robust bioprocesses for their expansion and analytical… read more here.
Keywords: cell; pluripotent stem; stem cells; bioprocess development ... See more keywords
Bioprocess Development and Characterization of a 13C-Labeled Hybrid Bispecific Antibody Produced in Escherichia coli
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DOI: 10.3390/antib12010016
Abstract: Monoclonal antibodies (mAbs) are highly efficacious therapeutics; however, due to their large, dynamic nature, structural perturbations and regional modifications are often difficult to study. Moreover, the homodimeric, symmetrical nature of mAbs makes it difficult to… read more here.
Keywords: hybrid bispecific; development characterization; bioprocess development; escherichia coli ... See more keywords
Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform
Sign Up to like & getrecommendations! Published in 2018 at "Bioengineering"
DOI: 10.3390/bioengineering5040101
Abstract: Mini-bioreactor systems enabling automatized operation of numerous parallel cultivations are a promising alternative to accelerate and optimize bioprocess development allowing for sophisticated cultivation experiments in high throughput. These include fed-batch and continuous cultivations with multiple… read more here.
Keywords: production; mini bioreactor; endopolygalacturonase; analysis ... See more keywords