Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500434
Abstract: Sugar nucleotides represent the cornerstone building blocks for glycan biosynthesis. While methods to access these crucial biomolecules using traditional batch synthetic chemistry and enzymatic approaches have blossomed, uptake using flow‐based synthesis is burgeoning. This perspective… read more here.
Keywords: sugar nucleotides; sugar; bioprocess optimization; advances challenges ... See more keywords
Bioprocess optimization for the overproduction of catalytic domain of ubiquitin-like protease 1 (Ulp1) from S. cerevisiae in E. coli fed-batch culture.
Sign Up to like & getrecommendations! Published in 2019 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2018.10.008
Abstract: The exploitation of SUMO (small ubiquitin-related modifier) fusion technology at a large scale for the production of therapeutic proteins with an authentic N-terminus is majorly limited due to the higher cost of ScUlp1 protease. Therefore,… read more here.
Keywords: catalytic domain; bioprocess optimization; protease; sculp1 protease ... See more keywords
Bioprocess optimization under uncertainty using ensemble modeling.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2017.01.013
Abstract: The performance of model-based bioprocess optimizations depends on the accuracy of the mathematical model. However, models of bioprocesses often have large uncertainty due to the lack of model identifiability. In the presence of such uncertainty,… read more here.
Keywords: bioprocess optimization; uncertainty; model; ensemble modeling ... See more keywords