Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507999
Abstract: Lignocellulosic biomass is a sustainable feedstock for biorefineries, but inefficient xylose utilization limits microbial bioproduction. Here, the oleaginous yeast Yarrowia lipolytica was engineered to produce succinic acid (SA) from xylose by resolving metabolic and regulatory… read more here.
Keywords: metabolism; bioproduction; yarrowia lipolytica; lignocellulosic biomass ... See more keywords
Peptide supplementation relieves stress and enhances glycolytic flux in filamentous fungi during organic acid bioproduction
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28152
Abstract: Filamentous fungi occupy a uniquely favorable position in the bioproduction of organic acids. Intracellular stress is the main stimulator in filamentous fungi to produce and accumulate organic acids with high flux. However, stress can affect… read more here.
Keywords: bioproduction; fermentation; filamentous fungi; fumaric acid ... See more keywords
Application of Genetic Engineering in Biotherapeutics Development
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-019-09411-6
Abstract: Purpose Advancements in genetic engineering have profoundly impacted the biotherapeutic industry and shaped many of the methods and strategies used today for both bioproduction and therapeutic design. Improvements in production yield and quality have been… read more here.
Keywords: application genetic; engineering; bioproduction; gene therapy ... See more keywords
Integrated process for scalable bioproduction of glycolic acid from cell catalysis of ethylene glycol.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2018.08.021
Abstract: Glycolic acid (GA) is presently booming as a versatile raw material in the fields of high-grade cosmetics, polymer degradable materials, and drug production. The biocatalysis of ethylene glycol (EG) to GA is promising, with environmentally… read more here.
Keywords: glycolic acid; bioproduction; ethylene glycol; cell catalysis ... See more keywords
Bioproduction of biomacromolecules for antiviral applications.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2021.01.022
Abstract: The societal damage brought on by viral epidemics indicates that next-generation antiviral treatments must be developed and deployed. Biomacromolecules are a diverse class of compounds that can potentially exhibit potent antiviral activity. Their efficacy and… read more here.
Keywords: bioproduction biomacromolecules; bioproduction; antiviral applications; biomacromolecules antiviral ... See more keywords
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00857
Abstract: Drug screening programs targeting novel indolethylamines with pharmacological properties suitable for the treatment of psychiatric and central nervous system disorders benefit from the availability of large compound libraries normally prepared using synthetic chemistry. Bioproduction strategies… read more here.
Keywords: chemistry; drug screening; biology; drug ... See more keywords
Antibiotics-Free Steady Bioproduction of Valuable Chemicals from Organic Wastes by Engineered Vibrio natriegens through Targeted Gene Integration.
Sign Up to like & getrecommendations! Published in 2024 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.4c00669
Abstract: Bioproduction of chemicals by using engineered bacteria is promising for a circular economy but challenged the instability of the introduced plasmid by conventional methods. Here, we developed a two-plasmid INTEGRET system to reliably integrate the… read more here.
Keywords: steady bioproduction; organic wastes; bioproduction; targeted gene ... See more keywords
ATP biosensor reveals microbial energetic dynamics and facilitates bioproduction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49579-1
Abstract: Adenosine-5’-triphosphate (ATP), the primary energy currency in cellular processes, drives metabolic activities and biosynthesis. Despite its importance, understanding intracellular ATP dynamics’ impact on bioproduction and exploiting it for enhanced bioproduction remains largely unexplored. Here, we… read more here.
Keywords: atp dynamics; bioproduction; atp biosensor; atp ... See more keywords
A biopiezocatalyst harnessing mechanical energy to enhance bioplastic production from CO2 and organic carbon
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DOI: 10.1038/s41467-025-63576-y
Abstract: The sustainable bioproduction of chemicals from CO2 remains far from reaching its full potential. The productivity of autotrophic bioprocesses could benefit from harnessing ubiquitous mechanical energy sources, which are inaccessible for energizing bioproduction systems to… read more here.
Keywords: energy; co2; mechanical energy; bioproduction ... See more keywords
Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2024.2438161
Abstract: Abstract This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects on various physiological processes, potential toxicity, and safety considerations, in order to… read more here.
Keywords: dendrobine also; dendrobine; circular economy; bioproduction ... See more keywords
Engineering the glyoxylate cycle for chemical bioproduction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1066651
Abstract: With growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes. Creating high-performance strains (with high titer, yield, and productivity) through metabolic… read more here.
Keywords: engineering glyoxylate; cycle; glyoxylate cycle; bioproduction ... See more keywords