Double-Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102059
Abstract: Heart valve has extraordinary fatigue resistance which beats ∼3 billion times in a lifetime. Bioprosthetic heart valves (BHVs) made from fixed heteroplasm that are incrementally used in heart valve replacement fail to sustain the expected… read more here.
Keywords: heart valves; heart; double network; bioprosthetic heart ... See more keywords
A novel anti-calcification method for bioprosthetic heart valves using dopamine-modified alginate
Sign Up to like & getrecommendations! Published in 2018 at "Polymer Bulletin"
DOI: 10.1007/s00289-018-2450-7
Abstract: Calcification is one of the main causes for bioprosthetic heart valves (BHVs)’ failure. Reported strategies to improve BHVs’ anti-calcification properties only target some of risk factors for calcification. In the current study, we demonstrated dopamine-modified… read more here.
Keywords: alginate; bioprosthetic heart; bhvs; calcification ... See more keywords
Poly-2-methyl-2-oxazoline–modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120694119
Abstract: Significance Heart valve disease affects millions, and since there is no effective medical therapy, surgical repair when possible—or more commonly, replacement—are the only treatments available. Bioprosthetic heart valves (BHV), the most frequently used valve replacements,… read more here.
Keywords: bioprosthetic heart; accumulation; age; heart valve ... See more keywords
Bioprosthetic heart valve structural degeneration associated with metabolic syndrome: Mitigation with polyoxazoline modification.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219054120
Abstract: Bioprosthetic heart valves (BHV), made from glutaraldehyde-fixed xenografts, are widely used for surgical and transcatheter valve interventions but suffer from limited durability due to structural valve degeneration (SVD). We focused on metabolic syndrome (MetS), a… read more here.
Keywords: bioprosthetic heart; degeneration; metabolic syndrome; polyoxazoline modification ... See more keywords
DOACs in Mechanical and Bioprosthetic Heart Valves: A Narrative Review of Emerging Data and Future Directions
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/10760296221103578
Abstract: In the recent years, there has been significant transformation in the management of valvular heart disease (VHD), as a result of new minimally invasive technologies, such as the transcatheter aortic valve implantation (TAVI). Conventionally, mechanical… read more here.
Keywords: bioprosthetic heart; emerging data; doacs mechanical; heart ... See more keywords
Dual-crosslinked Bioprosthetic Heart Valves Prepared by Glutaraldehyde Crosslinked Pericardium and Poly-2-hydroxyethyl Methacrylate Exhibited Improved Antithrombogenicity and Anticalcification Properties.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.2139/ssrn.4186613
Abstract: Bioprosthetic heart valves (BHVs) have been widely used due to the revolutionary transcatheter aortic valve replacement (TAVR) techniques but suffer from a limited lifespan. Previous modification methods of BHVs mainly rely on glutaraldehyde precrosslinking and… read more here.
Keywords: bioprosthetic heart; pericardium; hema; hydroxyethyl methacrylate ... See more keywords
The hybrid crosslinking method improved the stability and anti-calcification properties of the bioprosthetic heart valves
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1008664
Abstract: The bioprosthetic heart valves (BHVs) are the best option for the treatment of valvular heart disease. Glutaraldehyde (Glut) is commonly used as the golden standard reagent for the crosslinking of BHVs. However, the obvious defects… read more here.
Keywords: bioprosthetic heart; calcification; method; stability ... See more keywords
Preliminary study of improving immune tolerance in vivo of bioprosthetic heart valves through a novel antigenic removal method
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1141247
Abstract: The durability of bioprosthetic heart valves is always compromised by the inherent antigenicity of biomaterials. Decellularization has been a promising approach to reducing the immunogenicity of biological valves. However, current methods are insufficient in eliminating… read more here.
Keywords: bioprosthetic heart; immune tolerance; removal; tolerance vivo ... See more keywords