Improving docosahexaenoic acid production by Schizochytrium sp. using a newly designed high‐oxygen‐supply bioreactor
Sign Up to like & getrecommendations! Published in 2017 at "Aiche Journal"
DOI: 10.1002/aic.15783
Abstract: A sufficiently high oxygen supply is crucial for high-cell-density cultivation of aerobic microorganisms, including Schizochytrium sp. We, therefore, designed a novel bioreactor enabling high-level oxygen supply, and its relevant process parameters and fermentation-stage characteristics were… read more here.
Keywords: bioreactor; dha; oxygen supply; schizochytrium ... See more keywords
Transesterification of castor oil catalyzed by a fermented solid produced by Burkholderia contaminans using a bioreactor coupled with ultrasound irradiation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2410
Abstract: In this work, ultrasound was used to assist the ethanolysis of castor oil in a solvent‐free system, catalyzed by a dry fermented solid containing the lipase from Burkholderia contaminans (BCFS). Reactions were done at 45°C.… read more here.
Keywords: fermented solid; castor oil; oil; bioreactor ... See more keywords
Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly (ε-Caprolactone) Scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201900078
Abstract: BACKGROUND Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical… read more here.
Keywords: bioreactor; perfusion culture; chondrogenic differentiation; perfusion ... See more keywords
Biotechnological potential of Zymotis-2 bioreactor for the cultivation of filamentous fungi.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100288
Abstract: BACKGROUND/AIM A new prototype of Solid-State Fermentation Bioreactor, namely "Zymotis-2 ",was developed to produce fungal spores. MAIN METHODS AND MAJOR RESULTS A fermentation process for fungal spores, and hydrolase enzymes (endo and exoglucanases, amylases) production… read more here.
Keywords: bioreactor; zymotis bioreactor; niger g131;
Experimental study of the topological flow transformations in an aerial vortex bioreactor with a floating washer.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200644
Abstract: BACKGROUND Research into the flow structure in an aerial vortex bioreactor is relevant for developing the methods for growing cell cultures. Determining the optimal cultivation condition for a certain process is especially important in the… read more here.
Keywords: aerial vortex; bioreactor; vortex bioreactor; study topological ... See more keywords
Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26500
Abstract: In regenerative medicine, computer models describing bioreactor processes can assist in designing optimal process conditions leading to robust and economically viable products. In this study, we started from a (3D) mechanistic model describing the growth… read more here.
Keywords: reduction; bioreactor; model; optimization ... See more keywords
Live imaging flow bioreactor for the simulation of articular cartilage regeneration after treatment with bioactive hydrogel
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26736
Abstract: Osteochondral defects (OCDs) are conditions affecting both cartilage and the underlying bone. Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting… read more here.
Keywords: hydrogel; regeneration; bioreactor; cartilage ... See more keywords
Downscaling screening cultures in a multifunctional bioreactor array‐on‐a‐chip for speeding up optimization of yeast‐based lactic acid bioproduction
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27338
Abstract: A key challenge for bioprocess engineering is the identification of the optimum process conditions for the production of biochemical and biopharmaceutical compounds using prokaryotic as well as eukaryotic cell factories. Shake flasks and bench‐scale bioreactor… read more here.
Keywords: bioprocess; production; bioreactor; bioreactor array ... See more keywords
Technoeconomic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27475
Abstract: Biopharmaceutical protein production using transgenic plant cell bioreactor processes offers advantages over microbial and mammalian cell culture platforms in its ability to produce complex biologics with simple chemically defined media and reduced biosafety concerns. A… read more here.
Keywords: production; transgenic rice; bioreactor; cell suspension ... See more keywords
Techno‐economic modeling and assessment of cultivated meat: Impact of production bioreactor scale
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28324
Abstract: Increases in global meat demands cannot be sustainably met with current methods of livestock farming, which has a substantial impact on greenhouse gas emissions, land use, water consumption, and farm animal welfare. Cultivated meat is… read more here.
Keywords: scale; bioreactor; impact; cultivated meat ... See more keywords
Economic improvement of continuous pharmaceutical production via the optimal control of a multifeed bioreactor
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2433
Abstract: Projections on the profitability of the pharmaceutical industry predict a large amount of growth in the coming years. Stagnation over the last 20 years in product development has led to the search for new processing… read more here.
Keywords: improvement; production; productivity; multifeed bioreactor ... See more keywords