Improving docosahexaenoic acid production by Schizochytrium sp. using a newly designed high‐oxygen‐supply bioreactor
Sign Up to like & getrecommendations! Published in 2017 at "Aiche Journal"
DOI: 10.1002/aic.15783
Abstract: A sufficiently high oxygen supply is crucial for high-cell-density cultivation of aerobic microorganisms, including Schizochytrium sp. We, therefore, designed a novel bioreactor enabling high-level oxygen supply, and its relevant process parameters and fermentation-stage characteristics were… read more here.
Keywords: bioreactor; dha; oxygen supply; schizochytrium ... See more keywords
3D‐Printed Microfluidic Bioreactor Incorporating Electrospun Scaffolds for Creating an Enhanced Kidney Epithelial Cell Microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.57939
Abstract: Chronic kidney disease stands as a significant global health challenge, exacerbated by an ongoing scarcity of available organs for transplantation. Kidney tissue engineering is emerging as a promising innovation in the development of in vitro kidney… read more here.
Keywords: cell microenvironment; printed microfluidic; cell; bioreactor ... See more keywords
Transesterification of castor oil catalyzed by a fermented solid produced by Burkholderia contaminans using a bioreactor coupled with ultrasound irradiation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2410
Abstract: In this work, ultrasound was used to assist the ethanolysis of castor oil in a solvent‐free system, catalyzed by a dry fermented solid containing the lipase from Burkholderia contaminans (BCFS). Reactions were done at 45°C.… read more here.
Keywords: fermented solid; castor oil; oil; bioreactor ... See more keywords
Cell line development and bioreactor process optimization for an atezolizumab biosimilar
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2704
Abstract: Checkpoint inhibitors are widely recognized immunotherapeutic drugs, known for their effectiveness in treating various cancers. Atezolizumab, targeting the immune checkpoint programmed death‐ligand 1, is successfully used to treat several types of cancers. Atezolizumab is a… read more here.
Keywords: bioreactor; process; cell line; development ... See more keywords
Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly (ε-Caprolactone) Scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201900078
Abstract: BACKGROUND Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical… read more here.
Keywords: bioreactor; perfusion culture; chondrogenic differentiation; perfusion ... See more keywords
Biotechnological potential of Zymotis-2 bioreactor for the cultivation of filamentous fungi.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100288
Abstract: BACKGROUND/AIM A new prototype of Solid-State Fermentation Bioreactor, namely "Zymotis-2 ",was developed to produce fungal spores. MAIN METHODS AND MAJOR RESULTS A fermentation process for fungal spores, and hydrolase enzymes (endo and exoglucanases, amylases) production… read more here.
Keywords: bioreactor; zymotis bioreactor; niger g131;
Experimental study of the topological flow transformations in an aerial vortex bioreactor with a floating washer.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202200644
Abstract: BACKGROUND Research into the flow structure in an aerial vortex bioreactor is relevant for developing the methods for growing cell cultures. Determining the optimal cultivation condition for a certain process is especially important in the… read more here.
Keywords: aerial vortex; bioreactor; vortex bioreactor; study topological ... See more keywords
Innovative fixed bed bioreactor platform: Enabling linearly scalable adherent cell biomanufacturing with real‐time biomass prediction from nutrient consumption
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300635
Abstract: Scalable single‐use adherent cell‐based biomanufacturing platforms are essential for unlocking the full potential of cell and gene therapies. The primary objective of this study is to design and develop a novel fixed bed bioreactor platform… read more here.
Keywords: adherent cell; cell; bioreactor; bioreactor platform ... See more keywords
Dialysis rolled scaffold bioreactor allows extended production of monoclonal antibody with reduced media use
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400249
Abstract: Rapidly expanding biopharmaceutical market demands more cost‐effective platforms to produce protein therapeutics. To this end, novel approaches, such as perfusion culture or concentrated fed‐batch, have been explored for higher yields and lower manufacturing costs. Although… read more here.
Keywords: culture; dialysis; bioreactor; dialysis rolled ... See more keywords
Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26500
Abstract: In regenerative medicine, computer models describing bioreactor processes can assist in designing optimal process conditions leading to robust and economically viable products. In this study, we started from a (3D) mechanistic model describing the growth… read more here.
Keywords: reduction; bioreactor; model; optimization ... See more keywords
Live imaging flow bioreactor for the simulation of articular cartilage regeneration after treatment with bioactive hydrogel
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26736
Abstract: Osteochondral defects (OCDs) are conditions affecting both cartilage and the underlying bone. Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting… read more here.
Keywords: hydrogel; regeneration; bioreactor; cartilage ... See more keywords