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Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01465
Abstract: Small-molecule prodrug approaches that can activate cancer therapeutics selectively in tumors are urgently needed. Here, we developed the first antitumor prodrugs designed for activation by thiol-manifold oxidoreductases, targeting the thioredoxin (Trx) system. The Trx system…
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Keywords:
thiol;
system;
cyclic dichalcogenides;
bioreductive prodrugs ... See more keywords