Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering
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DOI: 10.1038/s41598-020-76855-z
Abstract: Affitins are a novel class of small 7 kDa artificial proteins which can be used as antibody substitutes in therapeutic, diagnostic and biotechnological applications. One challenge for this type of protein agent is their behaviour… read more here.
Keywords: protein; biorelevant media; protein engineering; digestion ... See more keywords
A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1810266
Abstract: Abstract Donepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions… read more here.
Keywords: donepezil hydrochloride; biorelevant media; sustainable uplc; method ... See more keywords
Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media
Sign Up to like & getrecommendations! Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1059-3
Abstract: Physiologically based absorption modeling has been attracting increased attention to study the interactions of weakly basic drug compounds with acid-reducing agents like proton-pump inhibitors and H2 blockers. Recently, standardized gastric and intestinal biorelevant media to… read more here.
Keywords: based absorption; absorption modeling; biorelevant media; physiologically based ... See more keywords
Stability of Biorelevant Media Under Various Storage Conditions
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DOI: 10.14227/dt260219p6
Abstract: The physical and chemical stability of various biorelevant media (FaSSGF, FaSSIF V1, FaSSIF V2, FaSSIF V3, and FeSSIF) were investigated over periods after preparation of up to 120 h at room temperature (RT) (22 °C)… read more here.
Keywords: time; fassif; stability; storage ... See more keywords
Role of Biorelevant Media in the Estimation of In Vitro Lipolysis and Food Impact on Self-emulsifying Drug Delivery Systems
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DOI: 10.2174/1574885515999200727121540
Abstract: Self-emulsifying drug delivery systems (SEDDS) include self-microemulsifying drug delivery system (SMEDDS) and self-nanoemulsifying drug delivery system (SNEDDS) whose major benefits are reduction of inter/intrasubject variability and food effect that results in a better pharmacological response… read more here.
Keywords: biorelevant media; drug delivery; drug; vitro lipolysis ... See more keywords
Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media
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DOI: 10.3390/pharmaceutics14020330
Abstract: Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance. Absorption… read more here.
Keywords: obtained biorelevant; precipitates obtained; biorelevant media; physicochemical properties ... See more keywords
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media
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DOI: 10.3390/pharmaceutics14040699
Abstract: The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of important questions… read more here.
Keywords: mucin; biorelevant media; permeability; drug permeation ... See more keywords
Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution
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DOI: 10.3390/pharmaceutics14102228
Abstract: Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in… read more here.
Keywords: dissolution; milk; biorelevant media; digestion ... See more keywords