Installing biosafety level 3 containment laboratories in low- and middle-income countries: challenges and prospects from Mali's experience
Sign Up to like & getrecommendations! Published in 2018 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2018.05.011
Abstract: In Mali, the incidence of tuberculosis (TB) is estimated at 56 cases per 100 000 people, with a prevalence of multidrug-resistant TB in new cases of 1.7% (range, 0.3–3.1%) and in retreatment cases of 17%… read more here.
Keywords: low middle; biosafety; middle income; biosafety level ... See more keywords
Burkholderia pseudomallei JW270 Is Lethal in the Madagascar Hissing Cockroach Infection Model and Can Be Utilized at Biosafety Level 2 to Identify Putative Virulence Factors
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00159-22
Abstract: Burkholderia pseudomallei, the causative agent of melioidosis, is classified by the CDC as a tier 1 select agent, and work involving it must be performed in a biosafety level 3 (BSL-3) laboratory. Three BSL-2 surrogate… read more here.
Keywords: biosafety level; burkholderia pseudomallei; virulence; jw270 ... See more keywords
Discovery of novel antifungal drugs via screening repurposing libraries against Coccidioides posadasii spherule initials
Sign Up to like & getrecommendations! Published in 2025 at "mBio"
DOI: 10.1128/mbio.00205-25
Abstract: ABSTRACT Coccidioidomycosis or valley fever is a treatment-limited fungal infection endemic to the alkaline deserts of North and South America for which two classes of antifungals are typically used: the polyenes and the triazoles. In… read more here.
Keywords: level containment; antifungals effective; drug; biosafety level ... See more keywords
Development of a Biosafety Level 1 Cellular Assay for Identifying Small-Molecule Antivirals Targeting the Main Protease of SARS-CoV-2: Evaluation of Cellular Activity of GC376, Boceprevir, Carmofur, Ebselen, and Selenoneine
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25115767
Abstract: While research has identified several inhibitors of the main protease (Mpro) of SARS-CoV-2, a significant portion of these compounds exhibit reduced activity in the presence of reducing agents, raising concerns about their effectiveness in vivo.… read more here.
Keywords: sars cov; main protease; gc376 boceprevir; biosafety level ... See more keywords
A Single-Round Infection Fluorescent SARS-CoV-2 Neutralization Test for COVID-19 Serological Testing at a Biosafety Level-2 Laboratory
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061211
Abstract: A robust serological test to measure neutralizing antibodies against SARS-CoV-2 in biosafety level-2 (BSL-2) laboratories is useful for monitoring antibody response after vaccination or natural infection. The gold standard assay is the conventional plaque reduction… read more here.
Keywords: biosafety level; infection; neutralization test; test ... See more keywords
Development of a novel positive pressure protective suit for Biosafety Level 4 laboratory in Japan.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2022.475
Abstract: Biosafety Level 4 (BSL-4) laboratories are necessary to study microorganisms that are highly pathogenic to humans and have no prevention or therapeutic measures. Currently, most BSL-4 facilities have suit-type laboratories to conduct experiments on highly… read more here.
Keywords: laboratory; biosafety level; suit; protective suit ... See more keywords