SAT0402 SEL-212 PHASE 2 CLINICAL STUDY IN SYMPTOMATIC GOUT PATIENTS: IMMTOR TOLEROGENIC NANOPARTICLES COMBINED WITH PEGADRICASE MITIGATES IMMUNOGENICITY AND ENABLES SUSTAINED REDUCTION OF SERUM URIC ACID LEVELS, LOW RATE OF GOUT FLARES AND MONTHLY DOSING
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7769
Abstract: Background: Pegylated uricases are promising therapies for the treatment of severe chronic gout, but are limited by their immunogenicity. We have previously shown that ImmTOR tolerogenic nanoparticles (formerly known as SVP-Rapamycin) encapsulating rapamycin co-administered with… read more here.
Keywords: biosciences inc; selecta biosciences; gout; gout flares ... See more keywords
A Phase 1a/b Dose Escalation Study of the MYC Repressor Apto-253 in Patients with Relapsed or Refractory AML or High-Risk MDS
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DOI: 10.1182/blood-2020-141409
Abstract: INTRODUCTION: APTO-253 is the only known small molecule in clinical development to target a conserved G-quadruplex structure in the promoter of the MYC oncogene and interrupt MYC gene expression. In preclinical studies of acute myeloid… read more here.
Keywords: aptose biosciences; inc current; biosciences inc; current equity ... See more keywords
6809 Natural History Of Classic Congenital Adrenal Hyperplasia: Results From Pediatric And Adult Patients In The CAHtalog Registry
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.244
Abstract: Abstract Disclosure: P.C. White: Consulting Fee; Self; Neurocrine Biosciences, Inc.. Research Investigator; Self; Neurocrine Biosciences, Inc. G.P. Sen: Employee; Self; Neurocrine Biosciences, Inc. F. Tang: Employee; Self; Cytel. J. Chen: Employee; Self; PicnicHealth. K. Lin-Su:… read more here.
Keywords: biosciences inc; history; neurocrine biosciences; employee self ... See more keywords
MON-458 Crinecerfont Allows for More Physiologic Glucocorticoid Dosing Regimens in Patients With Classic Congenital Adrenal Hyperplasia: Results from the Phase 3 CAHtalyst™ Adult and CAHtalystTM Pediatric Studies
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.216
Abstract: Abstract Disclosure: N. Nokoff: Consultant for Neurocrine Biosciences, Inc.; expert panel member for World Athletics. K.B. Krishna: None. L. Antonio: Sandoz, Merck, Advisory board member for Simple Pharma. R.H. Farber: Full-time employee of Neurocrine Biosciences,… read more here.
Keywords: adult; biosciences inc; neurocrine biosciences; dex ... See more keywords
MON-466 Crinecerfont Enables Reduction of Glucocorticoid Doses While Maintaining or Improving Androstenedione in Adults with Classic Congenital Adrenal Hyperplasia: Subgroup Analyses From the Phase 3 CAHtalyst™ Adult Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.224
Abstract: Abstract Disclosure: D.P. Merke: Research funding from Diurnal Limited, Neurocrine Biosciences, Inc., and Adrenas Therapeutics, and the National Institutes of Health Cooperative Research and Development Agreements, Received royalties from UpToDate for writing and editing. E.A.… read more here.
Keywords: week; biosciences inc; neurocrine biosciences; maintaining improving ... See more keywords
SAT-418 Crinecerfont Allows for More Physiologic Glucocorticoid Treatment With Reduction of Androstenedione to a Normal Range in Pediatric Patients With Classic Congenital Adrenal Hyperplasia: Post Hoc Analysis of the CAHtalyst™ Pediatric Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.286
Abstract: Abstract Disclosure: M. Lodish: Consultant for Neurocrine Biosciences, Inc. P.Y. Fechner: Research supportfrom Neurocrine Bioscience, Spruce Bioscience, and Diurnal UK Ltd and have served on an advisory board as a consultant for Neurocrine Bioscience. L.N.… read more here.
Keywords: week; biosciences inc; neurocrine biosciences; post hoc ... See more keywords
817-P: A Weekly Tension Off-Loading Patch for Lipohypertrophy
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DOI: 10.2337/db25-817-p
Abstract: Introduction and Objective: Besides injection site avoidance, there is no treatment for lipohypertrophy (LH), a common complication of insulin therapy associated with variable, impaired insulin absorption and suboptimal glycemic control. We investigated a tension offloading… read more here.
Keywords: patch; biosciences inc; histology; neodyne biosciences ... See more keywords